Handheld Adaptive Optics Scanning Laser Ophthalmoscope.

Journal Article (Journal Article)

Adaptive optics scanning laser ophthalmoscopy (AOSLO) has enabled in vivo visualization and enhanced understanding of retinal structure and function. Current generation AOSLOs have a large footprint and are mainly limited to imaging cooperative adult subjects. To extend the application of AOSLO to new patient populations, we have designed the first portable handheld AOSLO (HAOSLO) system. By incorporating a novel computational wavefront sensorless AO algorithm and custom optics, we have miniaturized our HAOSLO to weigh less than 200 grams. HAOSLO imaged the cones closest to the fovea with a handheld probe in adults and captured the first AO-enhanced image of cones in infants.

Full Text

Duke Authors

Cited Authors

  • DuBose, T; Nankivil, D; LaRocca, F; Waterman, G; Hagan, K; Polans, J; Keller, B; Tran-Viet, D; Vajzovic, L; Kuo, AN; Toth, CA; Izatt, JA; Farsiu, S

Published Date

  • September 20, 2018

Published In

Volume / Issue

  • 5 / 9

Start / End Page

  • 1027 - 1036

PubMed ID

  • 31745495

Pubmed Central ID

  • PMC6863352

International Standard Serial Number (ISSN)

  • 2334-2536

Digital Object Identifier (DOI)

  • 10.1364/OPTICA.5.001027


  • eng

Conference Location

  • United States