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Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm.

Publication ,  Journal Article
Duncan, AF; Bann, CM; Dempsey, A; Peralta-Carcelen, M; Hintz, S ...
Published in: J Pediatr
January 2019

OBJECTIVE: To investigate associations in toddlers born extremely preterm (<28 weeks) between neonatal neuroimaging and 18- to 22-month developmental and behavioral outcomes. STUDY DESIGN: Cohort analysis from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Surfactant Positive Airway Pressure and Pulse Oximetry Trial Neuroimaging and Neurodevelopmental Outcomes Study of infants born extremely preterm. Subjects underwent cranial ultrasonography and near-term magnetic resonance imaging (MRI). At 18-22 months of corrected age, the assessment included the Brief Infant Toddler Social Emotional Assessment (BITSEA) Problem and Competence Scale scores and the Bayley Scales of Infant Development, Third Edition (Bayley-III). The BITSEA Problem Scale assesses dysregulation; the Competence Scale assesses social-emotional competence. We examined associations of Problem and Competence scores and positive screen rates with cranial ultrasonography and near-term MRI. Mean BITSEA and Bayley-III scores were compared using ANOVA and positive screen rates with the χ2 test. We computed correlations between BITSEA and Bayley-III scores. RESULTS: Of the 397 children, positive BITSEA screens were found in 34% for the Problem score and 26% for the Competence score. Presence of lesions on near-term MRI that included cerebellar lesions were significantly associated with lower BITSEA Competence but not with Problem scores; Competence scores were inversely related to the presence/significance of lesions. Positive screens on Competence scores and on both Competence and Problem scores were significantly associated with Bayley-III cognitive and language scores <85 (P < .001). CONCLUSIONS: Social-emotional competence contributes to deficits in cognitive and language development. Presence of injury on near-term MRI that includes cerebellar lesions is associated with later social-emotional competence and may be a useful predictor to guide early assessment and intervention. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00063063 and NCT00233324.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

January 2019

Volume

204

Start / End Page

148 / 156.e4

Location

United States

Related Subject Headings

  • Ultrasonography, Doppler, Transcranial
  • Prospective Studies
  • Pediatrics
  • Neuropsychological Tests
  • Neuroimaging
  • Neurodevelopmental Disorders
  • Male
  • Magnetic Resonance Imaging
  • Infant, Extremely Premature
  • Infant
 

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Duncan, A. F., Bann, C. M., Dempsey, A., Peralta-Carcelen, M., Hintz, S., & Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network, . (2019). Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm. J Pediatr, 204, 148-156.e4. https://doi.org/10.1016/j.jpeds.2018.08.059
Duncan, Andrea F., Carla M. Bann, Allison Dempsey, Myriam Peralta-Carcelen, Susan Hintz, and Susan Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network. “Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm.J Pediatr 204 (January 2019): 148-156.e4. https://doi.org/10.1016/j.jpeds.2018.08.059.
Duncan AF, Bann CM, Dempsey A, Peralta-Carcelen M, Hintz S, Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network. Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm. J Pediatr. 2019 Jan;204:148-156.e4.
Duncan, Andrea F., et al. “Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm.J Pediatr, vol. 204, Jan. 2019, pp. 148-156.e4. Pubmed, doi:10.1016/j.jpeds.2018.08.059.
Duncan AF, Bann CM, Dempsey A, Peralta-Carcelen M, Hintz S, Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network. Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm. J Pediatr. 2019 Jan;204:148-156.e4.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

January 2019

Volume

204

Start / End Page

148 / 156.e4

Location

United States

Related Subject Headings

  • Ultrasonography, Doppler, Transcranial
  • Prospective Studies
  • Pediatrics
  • Neuropsychological Tests
  • Neuroimaging
  • Neurodevelopmental Disorders
  • Male
  • Magnetic Resonance Imaging
  • Infant, Extremely Premature
  • Infant