Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study.

Journal Article (Journal Article)

BACKGROUND: Oxidative stress is an important theory of aging but population-based evidence has been lacking. This study aimed to evaluate the associations between biomarkers of oxidative stress, including plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA), with all-cause mortality in older adults. METHODS: This is a community-based cohort study of 2224 participants (women:1227, median age: 86 years). We included individuals aged 65 or above and with plasma SOD activity and/or MDA tests at baseline. We evaluated the hazard ratios (HRs) and 95% confidence intervals (CIs) by multivariable Cox models. RESULTS: We documented 858 deaths during six years of follow-up. There was a significant interaction effect of sex with the association between SOD activity and mortality (P < 0.001). Compared with the lowest quintile, the risk of all-cause mortality was inversely associated with increasing quintiles of plasma SOD activity in women(P-trend< 0.001), with adjusted HRs for the second through fifth quintiles of 0.73 (95% CI 0.53-1.02), 0.52(95% CI 0.38-0.72), 0.53(95% CI 0.39-0.73), and 0.48(95% CI 0.35-0.66). There were no significant associations between SOD activity and mortality in men (P-trend = 0.64), and between MDA and mortality in all participants (P-trend = 0.79). CONCLUSIONS: Increased activity of SOD was independently associated with lower all-cause mortality in older women but not in men. This epidemiological study lent support for the free radical/oxidative stress theory of aging.

Full Text

Duke Authors

Cited Authors

  • Mao, C; Yuan, J-Q; Lv, Y-B; Gao, X; Yin, Z-X; Kraus, VB; Luo, J-S; Chei, C-L; Matchar, DB; Zeng, Y; Shi, X-M

Published Date

  • April 15, 2019

Published In

Volume / Issue

  • 19 / 1

Start / End Page

  • 104 -

PubMed ID

  • 30987591

Pubmed Central ID

  • PMC6466801

Electronic International Standard Serial Number (EISSN)

  • 1471-2318

Digital Object Identifier (DOI)

  • 10.1186/s12877-019-1109-z


  • eng

Conference Location

  • England