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Late growth of infantile hemangiomas in children >3 years of age: A retrospective study.

Publication ,  Journal Article
O'Brien, KF; Shah, SD; Pope, E; Phillips, RJ; Blei, F; Baselga, E; Garzon, MC; McCuaig, C; Haggstrom, AN; Hoeger, PH; Treat, JR; Perman, MJ ...
Published in: J Am Acad Dermatol
February 2019

BACKGROUND: The proliferative phase of infantile hemangiomas (IHs) is usually complete by 9 months of life. Late growth beyond age 3 years is rarely reported. OBJECTIVE: To describe the demographic and clinic characteristics of a cohort of patients with late growth of IH, defined as growth in a patient >3 years of age. METHODS: A multicenter, retrospective cohort study. RESULTS: In total, 59 patients, 85% of which were female, met the inclusion criteria. The mean first episode of late growth was 4.3 (range 3-8.5) years. Head and neck location (55/59; 93%) and presence of deep hemangioma (52/59; 88%) were common characteristics. Posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities (PHACE) syndrome was noted in 20 of 38 (53%) children with segmental facial IH. Systemic therapy (corticosteroid or β-blocker) was given during infancy in 58 of 59 (98%) and 24 of 59 (41%) received systemic therapy (β-blockers) for late IH growth. LIMITATIONS: The retrospective nature and ascertainment by investigator recall are limitations of the study. CONCLUSION: Late IH growth can occur in children after 3 years of age. Risk factors include head and neck location, segmental morphology, and involvement of deep dermal/subcutaneous tissues.

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Published In

J Am Acad Dermatol

DOI

EISSN

1097-6787

Publication Date

February 2019

Volume

80

Issue

2

Start / End Page

493 / 499

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Skin Neoplasms
  • Severity of Illness Index
  • Risk Assessment
  • Retrospective Studies
  • Propranolol
  • Male
  • Laser Therapy
 

Citation

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O’Brien, K. F., Shah, S. D., Pope, E., Phillips, R. J., Blei, F., Baselga, E., … Frieden, I. J. (2019). Late growth of infantile hemangiomas in children >3 years of age: A retrospective study. J Am Acad Dermatol, 80(2), 493–499. https://doi.org/10.1016/j.jaad.2018.07.061
O’Brien, Kathleen F., Sonal D. Shah, Elena Pope, Roderic J. Phillips, Francine Blei, Eulalia Baselga, Maria C. Garzon, et al. “Late growth of infantile hemangiomas in children >3 years of age: A retrospective study.J Am Acad Dermatol 80, no. 2 (February 2019): 493–99. https://doi.org/10.1016/j.jaad.2018.07.061.
O’Brien KF, Shah SD, Pope E, Phillips RJ, Blei F, Baselga E, et al. Late growth of infantile hemangiomas in children >3 years of age: A retrospective study. J Am Acad Dermatol. 2019 Feb;80(2):493–9.
O’Brien, Kathleen F., et al. “Late growth of infantile hemangiomas in children >3 years of age: A retrospective study.J Am Acad Dermatol, vol. 80, no. 2, Feb. 2019, pp. 493–99. Pubmed, doi:10.1016/j.jaad.2018.07.061.
O’Brien KF, Shah SD, Pope E, Phillips RJ, Blei F, Baselga E, Garzon MC, McCuaig C, Haggstrom AN, Hoeger PH, Treat JR, Perman MJ, Bellet JS, Cubiró X, Poole J, Frieden IJ. Late growth of infantile hemangiomas in children >3 years of age: A retrospective study. J Am Acad Dermatol. 2019 Feb;80(2):493–499.
Journal cover image

Published In

J Am Acad Dermatol

DOI

EISSN

1097-6787

Publication Date

February 2019

Volume

80

Issue

2

Start / End Page

493 / 499

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Skin Neoplasms
  • Severity of Illness Index
  • Risk Assessment
  • Retrospective Studies
  • Propranolol
  • Male
  • Laser Therapy