Benign gynecologic conditions are associated with ovarian cancer risk in African-American women: a case-control study.

Published

Journal Article

BACKGROUND: The association between common benign gynecologic conditions and ovarian cancer remains under-studied in African Americans. Therefore, we examine the association between self-reported history of benign gynecologic conditions and epithelial ovarian cancer risk in African-American women. METHODS: Data from a large population-based, multi-center case-control study of epithelial ovarian cancer in African-American women were analyzed to estimate the association between self-reported history of endometriosis, pelvic inflammatory disease (PID), fibroid, and ovarian cyst with epithelial ovarian cancer. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for the associations between individual and composite gynecologic conditions and ovarian cancer. RESULTS: 600 cases and 752 controls enrolled in the African American Cancer Epidemiology Study between 1 December 2010 and 31 December 2015 comprised the study population. After adjusting for potential confounders, a history of endometriosis was associated with ovarian cancer (OR 1.78; 95% CI 1.09-2.90). A non-significant association of similar magnitude was observed with PID (OR 1.33; 95% CI 0.82-2.16), while no association was observed in women with a history of fibroid or ovarian cyst. A positive trend was observed for an increasing number of reported gynecologic conditions (p = 0.006) with consistency across histologic subtypes and among both oral contraceptive users and non-users. CONCLUSION: A self-reported history of endometriosis among African-American women was associated with increased risk of ovarian cancer. Having multiple benign gynecologic conditions also increased ovarian cancer risk.

Full Text

Duke Authors

Cited Authors

  • Park, HK; Schildkraut, JM; Alberg, AJ; Bandera, EV; Barnholtz-Sloan, JS; Bondy, M; Crankshaw, S; Funkhouser, E; Moorman, PG; Peters, ES; Terry, P; Wang, F; Ruterbusch, JJ; Schwartz, AG; Cote, ML

Published Date

  • November 2018

Published In

Volume / Issue

  • 29 / 11

Start / End Page

  • 1081 - 1091

PubMed ID

  • 30269307

Pubmed Central ID

  • 30269307

Electronic International Standard Serial Number (EISSN)

  • 1573-7225

Digital Object Identifier (DOI)

  • 10.1007/s10552-018-1082-4

Language

  • eng

Conference Location

  • Netherlands