Quantitative and synthetic biology approaches to combat bacterial pathogens.

Journal Article (Journal Article)

Antibiotic resistance is one of the biggest threats to public health. The rapid emergence of resistant bacterial pathogens endangers the efficacy of current antibiotics and has led to increasing mortality and economic burden. This crisis calls for more rapid and accurate diagnosis to detect and identify pathogens, as well as to characterize their response to antibiotics. Building on this foundation, treatment options also need to be improved to use current antibiotics more effectively and develop alternative strategies that complement the use of antibiotics. We here review recent developments in diagnosis and treatment of bacterial pathogens with a focus on quantitative biology and synthetic biology approaches.

Full Text

Duke Authors

Cited Authors

  • Wu, F; Bethke, JH; Wang, M; You, L

Published Date

  • December 2017

Published In

Volume / Issue

  • 4 /

Start / End Page

  • 116 - 126

PubMed ID

  • 30263975

Pubmed Central ID

  • PMC6152938

Electronic International Standard Serial Number (EISSN)

  • 2468-4511

International Standard Serial Number (ISSN)

  • 2468-4511

Digital Object Identifier (DOI)

  • 10.1016/j.cobme.2017.10.007


  • eng