Effects of magnesium supplementation in a porcine model of myocardial ischemia and reperfusion.
Journal Article (Journal Article)
We tested the hypothesis that acute, intravenous (i.v.) magnesium (Mg2+) supplementation would protect against myocardial stunning in an in situ swine model of regional ischemia and reperfusion and that a concomitant inhibitory effect on platelet aggregation would be elicited. An open-chest model was used, with transient occlusion of the left anterior descending coronary artery (LAD) for 8 min. Regional contractile function was assessed by measuring wall thickening fraction with epicardial Doppler crystals. One control group (n = 6) and two treatment groups were studied: group I (n = 6) received 750 mg MgSO4 before occlusion; group II (n = 6) received 1 g MgSO4 after the occlusion. Both protocols produced significant hypermagnesemia. In group I, platelet aggregation was measured before and after Mg2+ treatment using platelet-rich plasma (PRP) and various agonists (ADP 5 and 10 mM and collagen 1 mg/ml). As compared with controls, both treatment groups experienced significantly less postischemic dysfunction, with systolic function returning more quickly to baseline. Furthermore, platelet aggregation was significantly decreased immediately after Mg2+ infusion. Inhibition of platelet aggregation induced by Mg2+ treatment occurs concomitantly with significant amelioration of postischemic myocardial dysfunction.
Full Text
Duke Authors
Cited Authors
- Atar, D; Serebruany, V; Poulton, J; Godard, J; Schneider, A; Herzog, WR
Published Date
- October 1994
Published In
Volume / Issue
- 24 / 4
Start / End Page
- 603 - 611
PubMed ID
- 7528843
International Standard Serial Number (ISSN)
- 0160-2446
Digital Object Identifier (DOI)
- 10.1097/00005344-199410000-00011
Language
- eng
Conference Location
- United States