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Coenzyme Q10 protects ischemic myocardium in an open-chest swine model.

Publication ,  Journal Article
Atar, D; Mortensen, SA; Flachs, H; Herzog, WR
Published in: Clin Investig
1993

Myocardial stunning, defined as a reversible decrease in contractility after ischemia and reperfusion, may be a manifestation of reperfusion injury caused by free oxygen radical damage. The aim of this study was to test the hypothesis that pretreatment with coenzyme Q10 (ubiquinone), believed to act as a free radical scavenger, reduces myocardial stunning in a porcine model. Twelve swine were randomized to receive either oral supplementation with coenzyme Q10 or placebo for 20 days. A normothermic open-chest model was used with short occlusion (8 min) of the distal left descending coronary artery followed by reperfusion. Regional contractile function was measured with epicardial Doppler crystals in ischemic and nonischemic segments by measuring thickening fraction of the left ventricular wall during systole. Stunning time was defined as the elapsed time of reduced contractility until return to baseline. Coenzyme Q10 concentrations were measured in blood and homogenized myocardial tissue by high performance liquid chromatography. Plasma levels of reduced coenzyme Q10 (ubiquinol) were higher in swine pretreated with the experimental medication as compared to placebo (mean 0.45 mg/l versus 0.11 mg/l, respectively). Myocardial tissue concentrations, however, did not show any changes (mean 0.79 micrograms/mg dry weight versus 0.74 micrograms/mg). Stunning time was significantly reduced in coenzyme Q10 pretreated animals (13.7 +/- 7.7 min versus 32.8 +/- 3.1 min, P < 0.01). In conclusion, chronic pretreatment with coenzyme Q10 protects ischemic myocardium in an open-chest swine model. The beneficial effect of coenzyme Q10 on myocardial stunning may be due to protection from free radical mediated reperfusion injury. This protective effect seems to be generated by a humoral rather than intracellular mechanism.

Duke Scholars

Published In

Clin Investig

DOI

ISSN

0941-0198

Publication Date

1993

Volume

71

Issue

8 Suppl

Start / End Page

S103 / S111

Location

Germany

Related Subject Headings

  • Ubiquinone
  • Swine
  • Random Allocation
  • Myocardial Stunning
  • Myocardial Ischemia
  • Immunology
  • Hemodynamics
  • Female
  • Drug Evaluation, Preclinical
  • Disease Models, Animal
 

Citation

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MLA
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Atar, D., Mortensen, S. A., Flachs, H., & Herzog, W. R. (1993). Coenzyme Q10 protects ischemic myocardium in an open-chest swine model. Clin Investig, 71(8 Suppl), S103–S111. https://doi.org/10.1007/BF00226849
Atar, D., S. A. Mortensen, H. Flachs, and W. R. Herzog. “Coenzyme Q10 protects ischemic myocardium in an open-chest swine model.Clin Investig 71, no. 8 Suppl (1993): S103–11. https://doi.org/10.1007/BF00226849.
Atar D, Mortensen SA, Flachs H, Herzog WR. Coenzyme Q10 protects ischemic myocardium in an open-chest swine model. Clin Investig. 1993;71(8 Suppl):S103–11.
Atar, D., et al. “Coenzyme Q10 protects ischemic myocardium in an open-chest swine model.Clin Investig, vol. 71, no. 8 Suppl, 1993, pp. S103–11. Pubmed, doi:10.1007/BF00226849.
Atar D, Mortensen SA, Flachs H, Herzog WR. Coenzyme Q10 protects ischemic myocardium in an open-chest swine model. Clin Investig. 1993;71(8 Suppl):S103–S111.

Published In

Clin Investig

DOI

ISSN

0941-0198

Publication Date

1993

Volume

71

Issue

8 Suppl

Start / End Page

S103 / S111

Location

Germany

Related Subject Headings

  • Ubiquinone
  • Swine
  • Random Allocation
  • Myocardial Stunning
  • Myocardial Ischemia
  • Immunology
  • Hemodynamics
  • Female
  • Drug Evaluation, Preclinical
  • Disease Models, Animal