Personalized mathematical model of endotoxin-induced inflammatory responses in young men and associated changes in heart rate variability


Journal Article

© EDP Sciences, 2018. The objective of this study was to develop a personalized inflammatory model and estimate subject-specific parameters that could be related to changes in heart rate variability (HRV), a measure that can be obtained non-invasively in real time. An inflammatory model was developed and calibrated to measurements of interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), interleukin-8 (IL-8) and interleukin-10 (IL-10) over 8 hours in 20 subjects administered a low dose of lipopolysaccharide. For this model, we estimated 11 subject-specific parameters for all 20 subjects. Estimated parameters were correlated with changes in HRV, computed from ECG measurements using a built-in HRV module available in Labchart. Results revealed that patients could be separated into two groups expressing normal and abnormal responses to endotoxin. Abnormal responders exhibited increased HRV, most likely as a result of increased vagal firing. The observed correlation between the inflammatory response and HRV brings us a step further towards understanding if HRV predictions can be used as a marker for inflammation. Analyzing HRV parameters provides an easy, non-invasively obtained measure that can be used to assess the state of the subject, potentially translating to identifying a non-invasive marker that can be used to detect the onset of sepsis.

Full Text

Duke Authors

Cited Authors

  • Brady, R; Frank-Ito, DO; Tran, HT; Janum, S; Møller, K; Brix, S; Ottesen, JT; Mehlsen, J; Olufsen, MS

Published Date

  • January 1, 2018

Published In

Volume / Issue

  • 13 / 5

Electronic International Standard Serial Number (EISSN)

  • 1760-6101

International Standard Serial Number (ISSN)

  • 0973-5348

Digital Object Identifier (DOI)

  • 10.1051/mmnp/2018031

Citation Source

  • Scopus