A randomized clinical trial of the effect of intraoperative saline perfusion on postvasectomy azoospermia.

Journal Article


We wanted to determine whether a saline flush during vasectomy would reduce the time needed to reach azoospermia.


During vasectomy men were randomly assigned to flush the prostatic end of the vas deferens with 10 mL of normal saline (intervention group, n = 50), while the remaining men (n = 56) served as controls. Sperm counts were performed on the immediate postprocedure urine specimen and on semen samples at 1, 6, and 12 weeks after vasectomy.


The postprocedure urine specimens from the intervention and control groups contained 29.2 x 106 and 0.004 x 106 sperm, respectively (P < .001). Total sperm counts in the ejaculate for intervention and control groups at 1, 6, and 12 weeks were (in millions of sperm): 14.1 and 13.8, 0.4 and 8.0, and 0.0 and 0.011, respectively (P > .05 at all time points). There was no difference in the rate at which the men in the 2 groups achieved azoospermia.


Vasal perfusion with saline during vasectomy was effective in removing sperm from the distal vas; however, perfusion did not increase the rate at which men achieve azoospermia.

Full Text

Duke Authors

Cited Authors

  • Eisner, B; Schuster, T; Rodgers, P; Ahmed, M; Faerber, G; Smith, G; Ohl, D

Published Date

  • May 2004

Published In

Volume / Issue

  • 2 / 3

Start / End Page

  • 221 - 223

PubMed ID

  • 15209198

Pubmed Central ID

  • 15209198

Electronic International Standard Serial Number (EISSN)

  • 1544-1717

International Standard Serial Number (ISSN)

  • 1544-1709

Digital Object Identifier (DOI)

  • 10.1370/afm.59


  • eng