Immunomodulator effect of picroliv and its potential in treatment against resistant Plasmodium yoelii (MDR) infection in mice.
Journal Article (Journal Article)
PURPOSE: The present study was envisaged to evaluate potential of combination therapy comprising of immunomodulator picroliv and antimalarial chloroquine against drug resistant Plasmodium yoelii (P. yoelii) infection in BALB/c mice. METHODS: The immunomodulatory potential of picroliv was established by immunizing animals with model antigen along with picroliv. Immune response was assessed using T-cell proliferation assay and also by determining the antibody isotype-profile induced in the immunized mice. In the next set of experiment, prophylactic potential of picroliv to strengthen antimalarial properties of chloroquine against P. yoelii (MDR) infection in BALB/c mice was assessed. RESULTS: T-cell proliferation as well as antibody production study reveals that picroliv helps in evoking strong immuno-potentiating response against model antigen in the immunized mice. Co-administration of picroliv enhances efficacy of CHQ against experimental murine malaria. CONCLUSION: The activation of host immune system can increase the efficacy of chloroquine for suppression of drug resistant malaria infection in BALB/c mice.
Full Text
Duke Authors
Cited Authors
- Dwivedi, V; Khan, A; Vasco, A; Fatima, N; Soni, VK; Dangi, A; Misra-Bhattacharya, S; Owais, M
Published Date
- October 2008
Published In
Volume / Issue
- 25 / 10
Start / End Page
- 2312 - 2319
PubMed ID
- 18551251
International Standard Serial Number (ISSN)
- 0724-8741
Digital Object Identifier (DOI)
- 10.1007/s11095-008-9631-2
Language
- eng
Conference Location
- United States