Harnessing Apoptotic Cells for Transplantation Tolerance: Current Status and Future Perspectives.

Journal Article (Journal Article)

PURPOSE OF REVIEW: The use of donor apoptotic cells is an emerging therapy for inducing transplantation tolerance. In this review, we will discuss current understanding of mechanisms of this approach, as well as crucial aspects necessary for successful translation of this approach to clinical transplantation. RECENT FINDINGS: Transplantation tolerance by donor apoptotic cells is mediated by their homeostatic interaction with recipient phagocytes, and subsequent expansion of suppressor cell populations as well as inhibition of effector T cells via deletion and anergy. To ensure their tolerogenicity, it is critical to procure non-stressed donor cells, and to induce and arrest their apoptosis at the appropriate stage prior to their administration. Equally important is the monitoring of dynamics of recipient immunological status, and its influences on tolerance efficacy and longevity. Emerging concepts and technologies may significantly streamline tolerogen manufacture and delivery of this approach, and smooth its transition to clinical application. SUMMARY: Hijacking homeostatic clearance of donor apoptotic cells is a promising strategy for transplantation tolerance. Timing is now mature for concerted efforts for transitioning this strategy to clinical transplantation.

Full Text

Duke Authors

Cited Authors

  • Dangi, A; Luo, X

Published Date

  • December 2017

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 270 - 279

PubMed ID

  • 29177124

Pubmed Central ID

  • PMC5697727

International Standard Serial Number (ISSN)

  • 2196-3029

Digital Object Identifier (DOI)

  • 10.1007/s40472-017-0167-4

Language

  • eng

Conference Location

  • Switzerland