The role of cavitation in acoustically activated drug delivery.

Published

Journal Article

Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from these polymeric carriers. In this study, an ultrasonic exposure chamber with fluorescence detection was used to examine the mechanism of doxorubicin release from P105 micelles. Acoustic spectra were collected and analyzed, at the same spatial position as fluorescence data, to probe the role of cavitation in drug release. Our study showed a strong correlation between percent drug release and subharmonic acoustic emissions, and we attribute the drug release to collapse cavitation that perturbs the structure of the micelle and releases drug.

Full Text

Duke Authors

Cited Authors

  • Husseini, GA; Diaz de la Rosa, MA; Richardson, ES; Christensen, DA; Pitt, WG

Published Date

  • October 2005

Published In

Volume / Issue

  • 107 / 2

Start / End Page

  • 253 - 261

PubMed ID

  • 16046023

Pubmed Central ID

  • 16046023

Electronic International Standard Serial Number (EISSN)

  • 1873-4995

International Standard Serial Number (ISSN)

  • 0168-3659

Digital Object Identifier (DOI)

  • 10.1016/j.jconrel.2005.06.015

Language

  • eng