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Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type.

Publication ,  Journal Article
Thompson, AC; McCall, CM; Proia, AD
Published in: Ocul Oncol Pathol
November 2018

PURPOSE: To report a case of extranodal natural killer/T-cell lymphoma (ENKTCL), nasal type metastatic to the space beneath the retinal pigment epithelium (RPE) with coincident paraneoplastic lymphoma-associated retinopathy. METHODS: Findings of clinical and histopathologic examination are presented with differential diagnoses and a literature review. CASE REPORT: A 53-year-old man presented with bilateral blindness and had exudative retinal detachments overlying subretinal masses in both eyes. Flow cytometry of pericardial fluid revealed malignant T lymphocytes. After two cycles of chemotherapy, the patient was hospitalized and quickly expired. Autopsy revealed lymphoma involving the eyes, heart, right lung, and two subcarinal lymph nodes focally. Histopathologic examination of the eyes revealed intraocular metastases from ENKTCL, nasal type. Expression of CD3 and CD56, along with expression of Epstein-Barr virus by in situ hybridization, confirmed the diagnosis. Lymphomatous infiltrates were confined to the space beneath the neurosensory retina and between the RPE and the Bruch membrane, sparing the uveal tissue, similar to other metastatic T-cell lymphomas. Extensive RPE and photoreceptor loss in regions with and without underlying tumor was typical of a concurrent paraneoplastic lymphoma-associated retinopathy. CONCLUSION: Patients diagnosed with ENKTCL should be evaluated by an ophthalmologist, as ophthalmic involvement portends a poor prognosis.

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Published In

Ocul Oncol Pathol

DOI

ISSN

2296-4681

Publication Date

November 2018

Volume

4

Issue

6

Start / End Page

388 / 394

Location

Switzerland
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Thompson, A. C., McCall, C. M., & Proia, A. D. (2018). Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type. Ocul Oncol Pathol, 4(6), 388–394. https://doi.org/10.1159/000487268
Thompson, Atalie C., Chad M. McCall, and Alan D. Proia. “Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type.Ocul Oncol Pathol 4, no. 6 (November 2018): 388–94. https://doi.org/10.1159/000487268.
Thompson, Atalie C., et al. “Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type.Ocul Oncol Pathol, vol. 4, no. 6, Nov. 2018, pp. 388–94. Pubmed, doi:10.1159/000487268.
Journal cover image

Published In

Ocul Oncol Pathol

DOI

ISSN

2296-4681

Publication Date

November 2018

Volume

4

Issue

6

Start / End Page

388 / 394

Location

Switzerland