Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial.

Published

Journal Article

OBJECTIVE: To assess whether length of hospital stay is decreased among moderately preterm infants weaned from incubator to crib at a lower vs higher weight. STUDY DESIGN: This trial was conducted in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Infants with gestational ages 29-33 weeks, birthweight <1600 g, and in an incubator were randomly assigned to a weaning weight of 1600 or 1800 g. Within 60 to 100 g of weaning weight, the incubator temperature was decreased by 1.0°C to 1.5°C every 24 hours until 28.0°C. The infants were weaned to the crib following stable temperature at 36.5°C to 37.4°C for 8 to 12 hours. Clothing and bedcoverings were standardized. The primary outcome was length of hospital stay from birth to discharge; secondary outcomes included length of stay and growth velocity from weaning to discharge. Adverse events were monitored. RESULTS: Of 1565 infants screened, 885 were eligible, and 366 enrolled-187 to the 1600-g and 179 to the 1800-g group. Maternal and neonatal characteristics did not differ among weight groups. Length of hospital stay was a median of 43 days in the lower and 41 days in the higher weight group (P = .12). Growth velocity from completion of weaning to discharge was higher in the lower weight group, 13.7 g/kg/day vs 12.8 g/kg/day (P = .005). Groups did not differ in adverse events. CONCLUSIONS: Among moderately preterm neonates, weaning from incubator to crib at a lower weight did not decrease length of stay, but was safe and was accompanied by higher weight gain after weaning. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02160002.

Full Text

Duke Authors

Cited Authors

  • Shankaran, S; Bell, EF; Laptook, AR; Saha, S; Newman, NS; Kazzi, SNJ; Barks, J; Stoll, BJ; Bara, R; Gabrio, J; Childs, K; Das, A; Higgins, RD; Carlo, WA; Sánchez, PJ; Carlton, DP; Pavageau, L; Malcolm, WF; D'Angio, CT; Ohls, RK; Poindexter, BB; Sokol, GM; Van Meurs, KP; Colaizy, TT; Khmour, A; Puopolo, KM; Garg, M; Walsh, MC; Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network,

Published Date

  • January 2019

Published In

Volume / Issue

  • 204 /

Start / End Page

  • 96 - 102.e4

PubMed ID

  • 30337189

Pubmed Central ID

  • 30337189

Electronic International Standard Serial Number (EISSN)

  • 1097-6833

Digital Object Identifier (DOI)

  • 10.1016/j.jpeds.2018.08.079

Language

  • eng

Conference Location

  • United States