Aspirin use during pregnancy and hypoxia-related placental pathology.

Journal Article (Journal Article)

OBJECTIVE: Aspirin has been shown to prevent preeclampsia. But the mechanisms remain unclear despite that improved placental circulation is considered as an underlying contributor. Our aim was to examine the hypoxia-related morphological and histopathological placental measures in relation to aspirin use during pregnancy. STUDY DESIGN: We used the Collaborative Perinatal Project (CPP) data, which is a cohort study conducted in the U.S. from 1959 to 1976. A total of 23, 604 women who had information on placental pathology and aspirin intake during pregnancy were included in the analysis. Among them, 1474 women had a history of hypertension or preeclampsia/eclampsia and were classified as a high-risk population; the rest were considered as a low-risk population. 47 placenta measures considered to be relevant to hypoxia were selected to build a composite hypoxia- related placenta index. The generalized linear mixed model was used to fit the relationship between aspirin and placental pathology. MAIN OUTCOME MEASURES: Hypoxia-related placental pathology. RESULTS: Aspirin use during pregnancy was associated with a reduced risk of hypoxia-related placental pathology in the high-risk population [the adjusted odds ratio and 95% confidence interval in the 1st, 2nd, and 3rd trimesters: 0.55 (0.31, 1.00), 0.76 (0.49, 1.17), and 0.53 (0.29, 0.94), respectively]. Longer duration of aspirin use in pregnancy tended to have a lower risk of hypoxia-related placental pathologies in the high-risk population. CONCLUSIONS: Aspirin use during pregnancy reduced risks of hypoxia-related placental pathologies in the high-risk women for preeclampsia. The duration of aspirin use determined its effects.

Full Text

Duke Authors

Cited Authors

  • Ye, J; Chen, Y; Zhu, J; Chen, C; Zhu, X; Feng, L; Ye, W; Zhang, J

Published Date

  • October 2018

Published In

Volume / Issue

  • 14 /

Start / End Page

  • 177 - 188

PubMed ID

  • 30527109

Electronic International Standard Serial Number (EISSN)

  • 2210-7797

Digital Object Identifier (DOI)

  • 10.1016/j.preghy.2018.07.009


  • eng

Conference Location

  • Netherlands