Skip to main content

Individual and Spatial Risk of Dengue Virus Infection in Puerto Maldonado, Peru.

Publication ,  Journal Article
Salmón-Mulanovich, G; Blazes, DL; Guezala V, MC; Rios, Z; Espinoza, A; Guevara, C; Lescano, AG; Montgomery, JM; Bausch, DG; Pan, WK
Published in: The American journal of tropical medicine and hygiene
December 2018

Dengue virus (DENV) affects more than 100 countries worldwide. Dengue virus infection has been increasing in the southern Peruvian Amazon city of Puerto Maldonado since 2000. We designed this study to describe the prevalence of past DENV infection and to evaluate risk factors. In 2012, we conducted a cross-sectional serosurvey and administered a knowledge, attitudes, and practices (KAP) questionnaire to members of randomly selected households. Sera were screened for antibodies to DENV by enzyme-linked immunosorbent assay and confirmed by plaque reduction neutralization test. We created indices for KAP (KAPi). We used SaTScan (Martin Kulldorff with Information Management Services Inc., Boston, MA) to detect clustering and created a multivariate model introducing the distance of households to potential vector and infection sources. A total of 505 participants from 307 households provided a blood sample and completed a questionnaire. Fifty-four percent of participants (95% confidence interval [CI]: 49.6; 58.5) had neutralizing antibodies to DENV. Higher values of KAPi were positively associated with having DENV antibodies in the multivariate analysis (odds ratio [ORII]: 1.6, 95% CI: 0.6, 2.4; ORIII: 2.7, 95% CI: 1.3, 5.5; and ORIV: 2.4, 95% CI: 1.2, 5.0). Older groups had lower chances of having been exposed to DENV than younger people (OR20-30: 0.5, 95% CI: 0.2, 0.8; OR31-45: 0.5, 95% CI: 0.3, 0.9; and OR>45: 0.6, 95% CI: 0.3, 1.3). Multivariate data analysis from the 270 households with location information showed male gender to have lower risk of past DENV infection (OR: 0.6, 95% CI: 0.4, 0.9). We conclude that risk of DENV infection in Puerto Maldonado is related to gender, age of the population, and location.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

The American journal of tropical medicine and hygiene

DOI

EISSN

1476-1645

ISSN

0002-9637

Publication Date

December 2018

Volume

99

Issue

6

Start / End Page

1440 / 1450

Related Subject Headings

  • Tropical Medicine
  • Surveys and Questionnaires
  • Sex Factors
  • Risk Factors
  • Prevalence
  • Peru
  • Mosquito Vectors
  • Middle Aged
  • Male
  • Infant, Newborn
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Salmón-Mulanovich, G., Blazes, D. L., Guezala V, M. C., Rios, Z., Espinoza, A., Guevara, C., … Pan, W. K. (2018). Individual and Spatial Risk of Dengue Virus Infection in Puerto Maldonado, Peru. The American Journal of Tropical Medicine and Hygiene, 99(6), 1440–1450. https://doi.org/10.4269/ajtmh.17-1015
Salmón-Mulanovich, Gabriela, David L. Blazes, M Claudia Guezala V, Zonia Rios, Angelica Espinoza, Carolina Guevara, Andrés G. Lescano, Joel M. Montgomery, Daniel G. Bausch, and William K. Pan. “Individual and Spatial Risk of Dengue Virus Infection in Puerto Maldonado, Peru.The American Journal of Tropical Medicine and Hygiene 99, no. 6 (December 2018): 1440–50. https://doi.org/10.4269/ajtmh.17-1015.
Salmón-Mulanovich G, Blazes DL, Guezala V MC, Rios Z, Espinoza A, Guevara C, et al. Individual and Spatial Risk of Dengue Virus Infection in Puerto Maldonado, Peru. The American journal of tropical medicine and hygiene. 2018 Dec;99(6):1440–50.
Salmón-Mulanovich, Gabriela, et al. “Individual and Spatial Risk of Dengue Virus Infection in Puerto Maldonado, Peru.The American Journal of Tropical Medicine and Hygiene, vol. 99, no. 6, Dec. 2018, pp. 1440–50. Epmc, doi:10.4269/ajtmh.17-1015.
Salmón-Mulanovich G, Blazes DL, Guezala V MC, Rios Z, Espinoza A, Guevara C, Lescano AG, Montgomery JM, Bausch DG, Pan WK. Individual and Spatial Risk of Dengue Virus Infection in Puerto Maldonado, Peru. The American journal of tropical medicine and hygiene. 2018 Dec;99(6):1440–1450.

Published In

The American journal of tropical medicine and hygiene

DOI

EISSN

1476-1645

ISSN

0002-9637

Publication Date

December 2018

Volume

99

Issue

6

Start / End Page

1440 / 1450

Related Subject Headings

  • Tropical Medicine
  • Surveys and Questionnaires
  • Sex Factors
  • Risk Factors
  • Prevalence
  • Peru
  • Mosquito Vectors
  • Middle Aged
  • Male
  • Infant, Newborn