Alcoholic liver disease


Book Section

© 2018 Elsevier Inc. All rights reserved. Consumption of alcohol is common in adults, and modest consumption has reported health benefits; however, chronic daily alcohol consumption above recommended limits is an important cause of chronic liver disease and cirrhosis. The amount and duration of alcohol consumption affect the likelihood of progression of alcoholic liver disease (ALD). The spectrum of ALD includes simple steatosis, alcoholic steatohepatitis, fibrosis, and cirrhosis, and the risk of hepatocellular carcinoma increases in more advanced disease. Alcoholic hepatitis (AH) is a potentially devastating acute form of ALD with a heightened risk of mortality. Furthermore, alcohol consumption promotes progression of liver disease in individuals with concomitant liver diseases, such as chronic viral hepatitis. Consequently, chronic alcohol consumption is associated with significant morbidity and mortality. Despite progress in understanding the pathophysiology of disease progression in ALD, no targeted therapies are available. The management of ALD relies on early recognition and complete abstinence from alcohol. Supportive care should focus on treating alcohol withdrawal and providing nutrition while managing the complications of chronic liver disease. Liver transplantation should be considered in individuals with advanced liver disease who achieve sobriety.

Full Text

Duke Authors

Cited Authors

  • Choi, SS; Diehl, AM

Published Date

  • January 1, 2018

Book Title

  • Handbook of Liver Disease

Start / End Page

  • 109 - 120

International Standard Book Number 13 (ISBN-13)

  • 9780323478748

Digital Object Identifier (DOI)

  • 10.1016/B978-0-323-47874-8.00008-0

Citation Source

  • Scopus