Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast


Book Section

© 2014 by Apple Academic Press, Inc. All organisms are exposed to proteotoxic stresses that result in the accumulation of misfolded proteins. In response to these stresses cells have evolved adaptive responses to protect and stabilize cellular proteins until more favorable conditions for cell proliferation are encountered [1]. The heat shock transcription factor, HSF, is a homotrimeric transcription factor that activates gene expression in response to a variety of stresses including heat and oxidative stress, as well as inflammation and infection [2]. Recent evidence has shown that the S. cerevisiae HSF directly activates the expression of genes whose protein products are involved in protein folding and degradation, ion transport, signal transduction, energy generation, carbohydrate metabolism, vesicular transport, cytoskeleton formation and other cellular functions [3].

Full Text

Duke Authors

Cited Authors

  • Batista-Nascimento, L; Neef, DW; Liu, PCC; Rodrigues-Pousada, C; Thiele, DJ

Published Date

  • January 1, 2014

Book Title

  • Investigations in Yeast Functional Genomics and Molecular Biology

Start / End Page

  • 129 - 154

International Standard Book Number 13 (ISBN-13)

  • 9781771880107

Digital Object Identifier (DOI)

  • 10.1201/b16586

Citation Source

  • Scopus