Anisotropic analysis of multi-component T2 and T1ρ relaxations in achilles tendon by NMR spectroscopy and microscopic MRI.


Journal Article

PURPOSE: To study the anisotropic characteristics of both multi-component T2 and T1ρ relaxation times in tendon. MATERIALS AND METHODS: T2 and T1ρ were measured in tendon by NMR spectroscopy at different orientations and by microscopic MRI at the magic angle. Several experimental issues in the multi-component relaxation measurements were investigated, including the effects of echo spacing, the resolution of MRI experiments, the influence of the specimen orientations, and the strengths of different spin-lock frequencies in T1ρ experiments. RESULTS: Both the values and fractions of T2 in tendon showed significant orientational dependence. The values and fractions of T1ρ strongly depended on both the specimen orientation and the spin-lock strength. The imaging resolution (35-280 μm) had little influence in the T2 experiments. Both the echo spacings (0.6-3.0 ms) in the T2 experiment and the spin-lock strengths (0.5-5 kHz) in the T1ρ experiment affected the quantification of the multi-component relaxation. Up to three T2 and T1ρ components were resolved in tendon. CONCLUSION: Multi-component relaxations could be attributed to different populations of water in the tissue. The transitions between a mono-component and multi-component result call for the caution in interpreting the relaxation results.

Full Text

Duke Authors

Cited Authors

  • Wang, N; Xia, Y

Published Date

  • September 2013

Published In

Volume / Issue

  • 38 / 3

Start / End Page

  • 625 - 633

PubMed ID

  • 23349070

Pubmed Central ID

  • 23349070

Electronic International Standard Serial Number (EISSN)

  • 1522-2586

Digital Object Identifier (DOI)

  • 10.1002/jmri.24012


  • eng

Conference Location

  • United States