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Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome.

Publication ,  Journal Article
Kilpatrick, LA; Kutch, JJ; Tillisch, K; Naliboff, BD; Labus, JS; Jiang, Z; Farmer, MA; Apkarian, AV; Mackey, S; Martucci, KT; Clauw, DJ ...
Published in: J Urol
September 2014

PURPOSE: The pathophysiology of interstitial cystitis/painful bladder syndrome remains incompletely understood but is thought to involve central disturbance in the processing of pain and viscerosensory signals. We identified differences in brain activity and connectivity between female patients with interstitial cystitis/painful bladder syndrome and healthy controls to advance clinical phenotyping and treatment efforts for interstitial cystitis/painful bladder syndrome. MATERIALS AND METHODS: We examined oscillation dynamics of intrinsic brain activity in a large sample of well phenotyped female patients with interstitial cystitis/painful bladder syndrome and female healthy controls. Data were collected during 10-minute resting functional magnetic resonance imaging as part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network project. The blood oxygen level dependent signal was transformed to the frequency domain. Relative power was calculated for multiple frequency bands. RESULTS: Results demonstrated altered frequency distributions in viscerosensory (post insula), somatosensory (postcentral gyrus) and motor regions (anterior paracentral lobule, and medial and ventral supplementary motor areas) in patients with interstitial cystitis/painful bladder syndrome. Also, the anterior paracentral lobule, and medial and ventral supplementary motor areas showed increased functional connectivity to the midbrain (red nucleus) and cerebellum. This increased functional connectivity was greatest in patients who reported pain during bladder filling. CONCLUSIONS: Findings suggest that women with interstitial cystitis/painful bladder syndrome have a sensorimotor component to the pathological condition involving an alteration in intrinsic oscillations and connectivity in a cortico-cerebellar network previously associated with bladder function.

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Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

September 2014

Volume

192

Issue

3

Start / End Page

947 / 955

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Nerve Net
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Cystitis, Interstitial
  • Brain
  • Adult
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Kilpatrick, L. A., Kutch, J. J., Tillisch, K., Naliboff, B. D., Labus, J. S., Jiang, Z., … Mayer, E. A. (2014). Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome. J Urol, 192(3), 947–955. https://doi.org/10.1016/j.juro.2014.03.093
Kilpatrick, Lisa A., Jason J. Kutch, Kirsten Tillisch, Bruce D. Naliboff, Jennifer S. Labus, Zhiguo Jiang, Melissa A. Farmer, et al. “Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome.J Urol 192, no. 3 (September 2014): 947–55. https://doi.org/10.1016/j.juro.2014.03.093.
Kilpatrick LA, Kutch JJ, Tillisch K, Naliboff BD, Labus JS, Jiang Z, et al. Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome. J Urol. 2014 Sep;192(3):947–55.
Kilpatrick, Lisa A., et al. “Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome.J Urol, vol. 192, no. 3, Sept. 2014, pp. 947–55. Pubmed, doi:10.1016/j.juro.2014.03.093.
Kilpatrick LA, Kutch JJ, Tillisch K, Naliboff BD, Labus JS, Jiang Z, Farmer MA, Apkarian AV, Mackey S, Martucci KT, Clauw DJ, Harris RE, Deutsch G, Ness TJ, Yang CC, Maravilla K, Mullins C, Mayer EA. Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome. J Urol. 2014 Sep;192(3):947–955.
Journal cover image

Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

September 2014

Volume

192

Issue

3

Start / End Page

947 / 955

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Nerve Net
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Cystitis, Interstitial
  • Brain
  • Adult
  • 3202 Clinical sciences
  • 1103 Clinical Sciences