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Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression.

Publication ,  Journal Article
Luz, NF; Khouri, R; Van Weyenbergh, J; Zanette, DL; Fiuza, PP; Noronha, A; Barral, A; Boaventura, VS; Prates, DB; Chan, FK-M; Andrade, BB; Borges, VM
Published in: Front Microbiol
2018

Leishmania braziliensis infection causes skin ulcers, typically found in localized cutaneous leishmaniasis (LCL). This tissue pathology associates with different modalities of cell necrosis, which are subverted by the parasite as a survival strategy. Herein we examined the participation of necroptosis, a specific form of programmed necrosis, in LCL lesions and found reduced RIPK3 and PGAM5 gene expression compared to normal skin. Assays using infected macrophages demonstrated that the parasite deactivates both RIPK3 and MLKL expression and that these molecules are important to control the intracellular L. braziliensis replication. Thus, LCL-related necroptosis may be targeted to control infection and disease immunopathology.

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Published In

Front Microbiol

DOI

ISSN

1664-302X

Publication Date

2018

Volume

9

Start / End Page

2283

Location

Switzerland

Related Subject Headings

  • 3207 Medical microbiology
  • 3107 Microbiology
  • 0605 Microbiology
  • 0503 Soil Sciences
  • 0502 Environmental Science and Management
 

Citation

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MLA
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Luz, N. F., Khouri, R., Van Weyenbergh, J., Zanette, D. L., Fiuza, P. P., Noronha, A., … Borges, V. M. (2018). Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression. Front Microbiol, 9, 2283. https://doi.org/10.3389/fmicb.2018.02283
Luz, Nivea F., Ricardo Khouri, Johan Van Weyenbergh, Dalila L. Zanette, Paloma P. Fiuza, Almerio Noronha, Aldina Barral, et al. “Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression.Front Microbiol 9 (2018): 2283. https://doi.org/10.3389/fmicb.2018.02283.
Luz NF, Khouri R, Van Weyenbergh J, Zanette DL, Fiuza PP, Noronha A, et al. Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression. Front Microbiol. 2018;9:2283.
Luz, Nivea F., et al. “Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression.Front Microbiol, vol. 9, 2018, p. 2283. Pubmed, doi:10.3389/fmicb.2018.02283.
Luz NF, Khouri R, Van Weyenbergh J, Zanette DL, Fiuza PP, Noronha A, Barral A, Boaventura VS, Prates DB, Chan FK-M, Andrade BB, Borges VM. Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression. Front Microbiol. 2018;9:2283.

Published In

Front Microbiol

DOI

ISSN

1664-302X

Publication Date

2018

Volume

9

Start / End Page

2283

Location

Switzerland

Related Subject Headings

  • 3207 Medical microbiology
  • 3107 Microbiology
  • 0605 Microbiology
  • 0503 Soil Sciences
  • 0502 Environmental Science and Management