Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression.
Journal Article
Leishmania braziliensis infection causes skin ulcers, typically found in localized cutaneous leishmaniasis (LCL). This tissue pathology associates with different modalities of cell necrosis, which are subverted by the parasite as a survival strategy. Herein we examined the participation of necroptosis, a specific form of programmed necrosis, in LCL lesions and found reduced RIPK3 and PGAM5 gene expression compared to normal skin. Assays using infected macrophages demonstrated that the parasite deactivates both RIPK3 and MLKL expression and that these molecules are important to control the intracellular L. braziliensis replication. Thus, LCL-related necroptosis may be targeted to control infection and disease immunopathology.
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Duke Authors
Cited Authors
- Luz, NF; Khouri, R; Van Weyenbergh, J; Zanette, DL; Fiuza, PP; Noronha, A; Barral, A; Boaventura, VS; Prates, DB; Chan, FK-M; Andrade, BB; Borges, VM
Published Date
- 2018
Published In
Volume / Issue
- 9 /
Start / End Page
- 2283 -
PubMed ID
- 30323793
Pubmed Central ID
- 30323793
International Standard Serial Number (ISSN)
- 1664-302X
Digital Object Identifier (DOI)
- 10.3389/fmicb.2018.02283
Language
- eng
Conference Location
- Switzerland