Developmental Morphogens & Recovery from Alcoholic Liver Disease.

Journal Article (Journal Article;Review)

Alcohol-induced steatohepatitis (ASH) increases the risk for both clinically-severe acute alcoholic hepatitis and eventual cirrhosis. The mechanisms that control ASH pathogenesis and progression are unclear but processes that regulate liver cell plasticity seem to be critically involved. In injured adult livers, morphogenic signaling pathways that modulate cell fate decisions during fetal development and in adult liver progenitors become reactivated. Overly-exuberant activation of such morphogenic signaling causes dysregulated liver repair and increases short- and long-term mortality by promoting acute liver failure, as well as progressive fibrosis. Hence, these pathways may be novel therapeutic targets to optimize liver cell reprogramming and prevent defective regenerative responses that cause acute liver failure and cirrhosis.

Full Text

Duke Authors

Cited Authors

  • Diehl, AM

Published Date

  • 2018

Published In

Volume / Issue

  • 1032 /

Start / End Page

  • 145 - 151

PubMed ID

  • 30362097

International Standard Serial Number (ISSN)

  • 0065-2598

Digital Object Identifier (DOI)

  • 10.1007/978-3-319-98788-0_11


  • eng

Conference Location

  • United States