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Developmental Morphogens & Recovery from Alcoholic Liver Disease.

Publication ,  Journal Article
Diehl, AM
Published in: Adv Exp Med Biol
2018

Alcohol-induced steatohepatitis (ASH) increases the risk for both clinically-severe acute alcoholic hepatitis and eventual cirrhosis. The mechanisms that control ASH pathogenesis and progression are unclear but processes that regulate liver cell plasticity seem to be critically involved. In injured adult livers, morphogenic signaling pathways that modulate cell fate decisions during fetal development and in adult liver progenitors become reactivated. Overly-exuberant activation of such morphogenic signaling causes dysregulated liver repair and increases short- and long-term mortality by promoting acute liver failure, as well as progressive fibrosis. Hence, these pathways may be novel therapeutic targets to optimize liver cell reprogramming and prevent defective regenerative responses that cause acute liver failure and cirrhosis.

Duke Scholars

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2018

Volume

1032

Start / End Page

145 / 151

Location

United States

Related Subject Headings

  • Signal Transduction
  • Regeneration
  • Liver Failure
  • Liver Cirrhosis
  • Liver
  • Humans
  • Hepatocytes
  • General & Internal Medicine
  • Fatty Liver, Alcoholic
  • Disease Progression
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Diehl, A. M. (2018). Developmental Morphogens & Recovery from Alcoholic Liver Disease. Adv Exp Med Biol, 1032, 145–151. https://doi.org/10.1007/978-3-319-98788-0_11
Diehl, Anna Mae. “Developmental Morphogens & Recovery from Alcoholic Liver Disease.Adv Exp Med Biol 1032 (2018): 145–51. https://doi.org/10.1007/978-3-319-98788-0_11.
Diehl AM. Developmental Morphogens & Recovery from Alcoholic Liver Disease. Adv Exp Med Biol. 2018;1032:145–51.
Diehl, Anna Mae. “Developmental Morphogens & Recovery from Alcoholic Liver Disease.Adv Exp Med Biol, vol. 1032, 2018, pp. 145–51. Pubmed, doi:10.1007/978-3-319-98788-0_11.
Diehl AM. Developmental Morphogens & Recovery from Alcoholic Liver Disease. Adv Exp Med Biol. 2018;1032:145–151.

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2018

Volume

1032

Start / End Page

145 / 151

Location

United States

Related Subject Headings

  • Signal Transduction
  • Regeneration
  • Liver Failure
  • Liver Cirrhosis
  • Liver
  • Humans
  • Hepatocytes
  • General & Internal Medicine
  • Fatty Liver, Alcoholic
  • Disease Progression