Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting.

Published

Journal Article

The goal of the Sexually Transmitted Infection Clinical Trial Group's Antimicrobial Resistance (AMR) in Neisseria gonorrhoeae (NG) meeting was to assemble experts from academia, government, nonprofit and industry to discuss the current state of research, gaps and challenges in research and technology and priorities and new directions to address the continued emergence of multidrug-resistant NG infections. Topics discussed at the meeting, which will be the focus of this article, include AMR NG global surveillance initiatives, the use of whole genome sequencing and bioinformatics to understand mutations associated with AMR, mechanisms of AMR, and novel antibiotics, vaccines and other methods to treat AMR NG. Key points highlighted during the meeting include: (i) US and International surveillance programs to understand AMR in NG; (ii) the US National Strategy for combating antimicrobial-resistant bacteria; (iii) surveillance needs, challenges, and novel technologies; (iv) plasmid-mediated and chromosomally mediated mechanisms of AMR in NG; (v) novel therapeutic (eg, sialic acid analogs, factor H [FH]/Fc fusion molecule, monoclonal antibodies, topoisomerase inhibitors, fluoroketolides, LpxC inhibitors) and preventative (eg, peptide mimic) strategies to combat infection. The way forward will require renewed political will, new funding initiatives, and collaborations across academic and commercial research and public health programs.

Full Text

Duke Authors

Cited Authors

  • Cristillo, AD; Bristow, CC; Torrone, E; Dillon, J-A; Kirkcaldy, RD; Dong, H; Grad, YH; Nicholas, RA; Rice, PA; Lawrence, K; Oldach, D; Shafer, WM; Zhou, P; Wi, TE; Morris, SR; Klausner, JD

Published Date

  • March 2019

Published In

Volume / Issue

  • 46 / 3

Start / End Page

  • e18 - e25

PubMed ID

  • 30363025

Pubmed Central ID

  • 30363025

Electronic International Standard Serial Number (EISSN)

  • 1537-4521

Digital Object Identifier (DOI)

  • 10.1097/OLQ.0000000000000929

Language

  • eng

Conference Location

  • United States