EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials.

Conference Paper

At a meeting of the EU/US/Clinical Trials in Alzheimer's Disease (CTAD) Task Force in December 2016, an international group of investigators from industry, academia, and regulatory agencies reviewed lessons learned from ongoing and planned prevention trials, which will help guide future clinical trials of AD treatments, particularly in the pre-clinical space. The Task Force discussed challenges that need to be addressed across all aspects of clinical trials, calling for innovation in recruitment and retention, infrastructure development, and the selection of outcome measures. While cognitive change provides a marker of disease progression across the disease continuum, there remains a need to identify the optimal assessment tools that provide clinically meaningful endpoints. Patient- and informant-reported assessments of cognition and function may be useful but present additional challenges. Imaging and other biomarkers are also essential to maximize the efficiency of and the information learned from clinical trials.

Full Text

Duke Authors

Cited Authors

  • Aisen, P; Touchon, J; Amariglio, R; Andrieu, S; Bateman, R; Breitner, J; Donohue, M; Dunn, B; Doody, R; Fox, N; Gauthier, S; Grundman, M; Hendrix, S; Ho, C; Isaac, M; Raman, R; Rosenberg, P; Schindler, R; Schneider, L; Sperling, R; Tariot, P; Welsh-Bohmer, K; Weiner, M; Vellas, B

Published Date

  • 2017

Published In

Volume / Issue

  • 4 / 2

Start / End Page

  • 116 - 124

PubMed ID

  • 29186281

Pubmed Central ID

  • PMC5724787

Electronic International Standard Serial Number (EISSN)

  • 2426-0266

Digital Object Identifier (DOI)

  • 10.14283/jpad.2017.13

Conference Location

  • Switzerland