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Acute and chronic phagocyte determinants of cardiac allograft vasculopathy.

Publication ,  Journal Article
Glinton, K; DeBerge, M; Yeap, X-Y; Zhang, J; Forbess, J; Luo, X; Thorp, EB
Published in: Semin Immunopathol
November 2018

Post-transplant immunosuppression has reduced the incidence of T cell-mediated acute rejection, yet long-term cardiac graft survival rates remain a challenge. An important determinant of chronic solid organ allograft complication is accelerated vascular disease of the transplanted graft. In the case of cardiac allograft vasculopathy (CAV), the precise cellular etiology remains inadequately understood; however, histologic evidence hints at the accumulation and activation of innate phagocytes as a causal contributing factor. This includes monocytes, macrophages, and immature dendritic cell subsets. In addition to crosstalk with adaptive T and B immune cells, myeloid phagocytes secrete paracrine signals that directly activate fibroblasts and vascular smooth muscle cells, both of which contribute to fibrous intimal thickening. Though maladaptive phagocyte functions may promote CAV, directed modulation of myeloid cell function, at the molecular level, holds promise for tolerance and prolonged cardiac graft function.

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Published In

Semin Immunopathol

DOI

EISSN

1863-2300

Publication Date

November 2018

Volume

40

Issue

6

Start / End Page

593 / 603

Location

Germany

Related Subject Headings

  • Vascular Diseases
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Immunologic
  • Phagocytes
  • Isoantigens
  • Immunology
  • Immunity, Innate
  • Hypoxia
  • Humans
 

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Glinton, K., DeBerge, M., Yeap, X.-Y., Zhang, J., Forbess, J., Luo, X., & Thorp, E. B. (2018). Acute and chronic phagocyte determinants of cardiac allograft vasculopathy. Semin Immunopathol, 40(6), 593–603. https://doi.org/10.1007/s00281-018-0699-4
Glinton, Kristofor, Matthew DeBerge, Xin-Yi Yeap, Jenny Zhang, Joseph Forbess, Xunrong Luo, and Edward B. Thorp. “Acute and chronic phagocyte determinants of cardiac allograft vasculopathy.Semin Immunopathol 40, no. 6 (November 2018): 593–603. https://doi.org/10.1007/s00281-018-0699-4.
Glinton K, DeBerge M, Yeap X-Y, Zhang J, Forbess J, Luo X, et al. Acute and chronic phagocyte determinants of cardiac allograft vasculopathy. Semin Immunopathol. 2018 Nov;40(6):593–603.
Glinton, Kristofor, et al. “Acute and chronic phagocyte determinants of cardiac allograft vasculopathy.Semin Immunopathol, vol. 40, no. 6, Nov. 2018, pp. 593–603. Pubmed, doi:10.1007/s00281-018-0699-4.
Glinton K, DeBerge M, Yeap X-Y, Zhang J, Forbess J, Luo X, Thorp EB. Acute and chronic phagocyte determinants of cardiac allograft vasculopathy. Semin Immunopathol. 2018 Nov;40(6):593–603.
Journal cover image

Published In

Semin Immunopathol

DOI

EISSN

1863-2300

Publication Date

November 2018

Volume

40

Issue

6

Start / End Page

593 / 603

Location

Germany

Related Subject Headings

  • Vascular Diseases
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Immunologic
  • Phagocytes
  • Isoantigens
  • Immunology
  • Immunity, Innate
  • Hypoxia
  • Humans