Immune Tolerance for Autoimmune Disease and Cell Transplantation.

Journal Article (Journal Article;Review)

The undesired destruction of healthy cells, either endogenous or transplanted, by the immune system results in the loss of tissue function or limits strategies to restore tissue function. Current therapies typically involve nonspecific immunosuppression that may prevent the appropriate response to an antigen, thereby decreasing humoral immunity and increasing the risks of patient susceptibility to opportunistic infections, viral reactivation, and neoplasia. The induction of antigen-specific immunological tolerance to block undesired immune responses to self- or allogeneic antigens, while maintaining the integrity of the remaining immune system, has the potential to transform the current treatment of autoimmune disease and serve as a key enabling technology for therapies based on cell transplantation.

Full Text

Duke Authors

Cited Authors

  • Luo, X; Miller, SD; Shea, LD

Published Date

  • July 11, 2016

Published In

Volume / Issue

  • 18 /

Start / End Page

  • 181 - 205

PubMed ID

  • 26928211

Pubmed Central ID

  • PMC4947009

Electronic International Standard Serial Number (EISSN)

  • 1545-4274

Digital Object Identifier (DOI)

  • 10.1146/annurev-bioeng-110315-020137


  • eng

Conference Location

  • United States