THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away.
Publication
, Journal Article
Khosravi-Maharlooei, M; Hajizadeh-Saffar, E; Tahamtani, Y; Basiri, M; Montazeri, L; Khalooghi, K; Kazemi Ashtiani, M; Farrokhi, A; Aghdami, N ...
Published in: Eur J Endocrinol
November 2015
Over the past decades, tremendous efforts have been made to establish pancreatic islet transplantation as a standard therapy for type 1 diabetes. Recent advances in islet transplantation have resulted in steady improvements in the 5-year insulin independence rates for diabetic patients. Here we review the key challenges encountered in the islet transplantation field which include islet source limitation, sub-optimal engraftment of islets, lack of oxygen and blood supply for transplanted islets, and immune rejection of islets. Additionally, we discuss possible solutions for these challenges.
Duke Scholars
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Published In
Eur J Endocrinol
DOI
EISSN
1479-683X
Publication Date
November 2015
Volume
173
Issue
5
Start / End Page
R165 / R183
Location
England
Related Subject Headings
- Islets of Langerhans Transplantation
- Humans
- Endocrinology & Metabolism
- Diabetes Mellitus, Type 1
- 3215 Reproductive medicine
- 3202 Clinical sciences
- 1114 Paediatrics and Reproductive Medicine
- 1103 Clinical Sciences
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ICMJE
MLA
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Khosravi-Maharlooei, M., Hajizadeh-Saffar, E., Tahamtani, Y., Basiri, M., Montazeri, L., Khalooghi, K., … Baharvand, H. (2015). THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away. Eur J Endocrinol, 173(5), R165–R183. https://doi.org/10.1530/EJE-15-0094
Khosravi-Maharlooei, Mohsen, Ensiyeh Hajizadeh-Saffar, Yaser Tahamtani, Mohsen Basiri, Leila Montazeri, Keynoosh Khalooghi, Mohammad Kazemi Ashtiani, et al. “THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away.” Eur J Endocrinol 173, no. 5 (November 2015): R165–83. https://doi.org/10.1530/EJE-15-0094.
Khosravi-Maharlooei M, Hajizadeh-Saffar E, Tahamtani Y, Basiri M, Montazeri L, Khalooghi K, et al. THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away. Eur J Endocrinol. 2015 Nov;173(5):R165–83.
Khosravi-Maharlooei, Mohsen, et al. “THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away.” Eur J Endocrinol, vol. 173, no. 5, Nov. 2015, pp. R165–83. Pubmed, doi:10.1530/EJE-15-0094.
Khosravi-Maharlooei M, Hajizadeh-Saffar E, Tahamtani Y, Basiri M, Montazeri L, Khalooghi K, Kazemi Ashtiani M, Farrokhi A, Aghdami N, Sadr Hashemi Nejad A, Larijani M-B, De Leu N, Heimberg H, Luo X, Baharvand H. THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away. Eur J Endocrinol. 2015 Nov;173(5):R165–R183.
Published In
Eur J Endocrinol
DOI
EISSN
1479-683X
Publication Date
November 2015
Volume
173
Issue
5
Start / End Page
R165 / R183
Location
England
Related Subject Headings
- Islets of Langerhans Transplantation
- Humans
- Endocrinology & Metabolism
- Diabetes Mellitus, Type 1
- 3215 Reproductive medicine
- 3202 Clinical sciences
- 1114 Paediatrics and Reproductive Medicine
- 1103 Clinical Sciences