THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away.
Over the past decades, tremendous efforts have been made to establish pancreatic islet transplantation as a standard therapy for type 1 diabetes. Recent advances in islet transplantation have resulted in steady improvements in the 5-year insulin independence rates for diabetic patients. Here we review the key challenges encountered in the islet transplantation field which include islet source limitation, sub-optimal engraftment of islets, lack of oxygen and blood supply for transplanted islets, and immune rejection of islets. Additionally, we discuss possible solutions for these challenges.
Khosravi-Maharlooei, M; Hajizadeh-Saffar, E; Tahamtani, Y; Basiri, M; Montazeri, L; Khalooghi, K; Kazemi Ashtiani, M; Farrokhi, A; Aghdami, N; Sadr Hashemi Nejad, A; Larijani, M-B; De Leu, N; Heimberg, H; Luo, X; Baharvand, H
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