THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away.

Journal Article (Journal Article;Review)

Over the past decades, tremendous efforts have been made to establish pancreatic islet transplantation as a standard therapy for type 1 diabetes. Recent advances in islet transplantation have resulted in steady improvements in the 5-year insulin independence rates for diabetic patients. Here we review the key challenges encountered in the islet transplantation field which include islet source limitation, sub-optimal engraftment of islets, lack of oxygen and blood supply for transplanted islets, and immune rejection of islets. Additionally, we discuss possible solutions for these challenges.

Full Text

Duke Authors

Cited Authors

  • Khosravi-Maharlooei, M; Hajizadeh-Saffar, E; Tahamtani, Y; Basiri, M; Montazeri, L; Khalooghi, K; Kazemi Ashtiani, M; Farrokhi, A; Aghdami, N; Sadr Hashemi Nejad, A; Larijani, M-B; De Leu, N; Heimberg, H; Luo, X; Baharvand, H

Published Date

  • November 2015

Published In

Volume / Issue

  • 173 / 5

Start / End Page

  • R165 - R183

PubMed ID

  • 26036437

Electronic International Standard Serial Number (EISSN)

  • 1479-683X

Digital Object Identifier (DOI)

  • 10.1530/EJE-15-0094

Language

  • eng

Conference Location

  • England