Steroidogenic factor 1: an essential mediator of endocrine development.

Journal Article (Journal Article;Review)

The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP and officially designated NR5A1) has emerged as an essential regulator of endocrine development and function. Initially identified as a tissue-specific transcriptional regulator of the cytochrome P450 steroid hydroxylases, SF-1 has considerably broader roles, as evidenced from studies in knockout mice lacking SF-1. The SF-1-knockout mice lacked adrenal glands and gonads and therefore died from adrenal insufficiency within the first week after birth. In addition, SF-1 knockout mice exhibited male-to-female sex reversal of their internal and external genitalia, impaired expression of multiple markers of pituitary gonadotropes, and agenesis of the ventromedial hypothalamic nucleus (VMH). These studies delineated essential roles of SF-I in regulating endocrine differentiation and function at multiple levels, particularly with respect to reproduction. This chapter will review the experiments that established SF-1 as a pivotal, global determinant of endocrine differentiation and function. We next discuss recent insights into the mechanisms controlling the expression and function of SF-1 as well as the current status of research aimed at delineating its roles in specific tissues. Finally, we highlight areas where additional studies are needed to expand our understanding of SF-1 action.

Full Text

Duke Authors

Cited Authors

  • Parker, KL; Rice, DA; Lala, DS; Ikeda, Y; Luo, X; Wong, M; Bakke, M; Zhao, L; Frigeri, C; Hanley, NA; Stallings, N; Schimmer, BP

Published Date

  • 2002

Published In

Volume / Issue

  • 57 /

Start / End Page

  • 19 - 36

PubMed ID

  • 12017543

International Standard Serial Number (ISSN)

  • 0079-9963

Digital Object Identifier (DOI)

  • 10.1210/rp.57.1.19


  • eng

Conference Location

  • United States