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Steroidogenic factor 1 (SF-1) is essential for ovarian development and function.

Publication ,  Journal Article
Hanley, NA; Ikeda, Y; Luo, X; Parker, KL
Published in: Mol Cell Endocrinol
May 25, 2000

The orphan nuclear receptor steroidogenic factor 1 (SF-1) was identified originally as a key regulator of the tissue-specific expression of the cytochrome P450 steroid hydroxylases. Hints at considerably broader roles for SF-1 came from analyses of its expression pattern in mouse embryos. As anticipated, SF-1 was expressed in the adrenal glands and gonads from their early stages of development. Surprisingly, SF-1 also was expressed outside of the primary steroidogenic tissues in the anterior pituitary and hypothalamus. SF-1 knockout mice dramatically confirmed its multiple essential roles in vivo. These mice lacked adrenal glands and gonads, leading to adrenocortical insufficiency and male-to-female sex reversal of their internal and external genitalia. SF-1 knockout mice also had impaired pituitary expression of gonadotropins and agenesis of the ventromedial hypothalamic nucleus (VMH), confirming roles of SF-1 at all three levels of the hypothalamic-pituitary-gonadal axis. With some focus on the ovary, this review summarizes experiments that have defined essential roles of SF-1 in endocrine development, and highlights important areas for future studies.

Duke Scholars

Published In

Mol Cell Endocrinol

DOI

ISSN

0303-7207

Publication Date

May 25, 2000

Volume

163

Issue

1-2

Start / End Page

27 / 32

Location

Ireland

Related Subject Headings

  • Transcription Factors
  • Steroidogenic Factor 1
  • Receptors, Cytoplasmic and Nuclear
  • Pituitary-Adrenal System
  • Ovary
  • Mice, Knockout
  • Mice
  • Male
  • Hypothalamo-Hypophyseal System
  • Humans
 

Citation

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Chicago
ICMJE
MLA
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Hanley, N. A., Ikeda, Y., Luo, X., & Parker, K. L. (2000). Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. Mol Cell Endocrinol, 163(1–2), 27–32. https://doi.org/10.1016/s0303-7207(99)00237-3
Hanley, N. A., Y. Ikeda, X. Luo, and K. L. Parker. “Steroidogenic factor 1 (SF-1) is essential for ovarian development and function.Mol Cell Endocrinol 163, no. 1–2 (May 25, 2000): 27–32. https://doi.org/10.1016/s0303-7207(99)00237-3.
Hanley NA, Ikeda Y, Luo X, Parker KL. Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. Mol Cell Endocrinol. 2000 May 25;163(1–2):27–32.
Hanley, N. A., et al. “Steroidogenic factor 1 (SF-1) is essential for ovarian development and function.Mol Cell Endocrinol, vol. 163, no. 1–2, May 2000, pp. 27–32. Pubmed, doi:10.1016/s0303-7207(99)00237-3.
Hanley NA, Ikeda Y, Luo X, Parker KL. Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. Mol Cell Endocrinol. 2000 May 25;163(1–2):27–32.
Journal cover image

Published In

Mol Cell Endocrinol

DOI

ISSN

0303-7207

Publication Date

May 25, 2000

Volume

163

Issue

1-2

Start / End Page

27 / 32

Location

Ireland

Related Subject Headings

  • Transcription Factors
  • Steroidogenic Factor 1
  • Receptors, Cytoplasmic and Nuclear
  • Pituitary-Adrenal System
  • Ovary
  • Mice, Knockout
  • Mice
  • Male
  • Hypothalamo-Hypophyseal System
  • Humans