Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells.
Journal Article (Journal Article;Review)
CD4(+)CD25(+) T cells were identified originally as potent suppressors of autoimmunity and were later termed "natural regulatory T cells" or nTreg cells. Subsequently, a transcription factor called forkhead box protein 3 (Foxp3) was identified to be a critical regulator for Treg differentiation and function. Foxp3(+)CD4(+)CD25(+) Treg cells have been increasingly documented to suppress allograft rejection and to mediate allograft tolerance in transplantation. In this article, the authors review current approaches for amplification of allo-specific Foxp3(+)CD4(+)CD25(+) Treg cells for prevention of allograft rejection and induction of allo-specific transplant tolerance.
Full Text
Duke Authors
Cited Authors
- Xia, G; Shah, M; Luo, X
Published Date
- February 2009
Published In
Volume / Issue
- 153 / 2
Start / End Page
- 60 - 70
PubMed ID
- 19138650
Pubmed Central ID
- PMC3408234
International Standard Serial Number (ISSN)
- 1931-5244
Digital Object Identifier (DOI)
- 10.1016/j.trsl.2008.12.001
Language
- eng
Conference Location
- United States