Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells.

Journal Article (Journal Article;Review)

CD4(+)CD25(+) T cells were identified originally as potent suppressors of autoimmunity and were later termed "natural regulatory T cells" or nTreg cells. Subsequently, a transcription factor called forkhead box protein 3 (Foxp3) was identified to be a critical regulator for Treg differentiation and function. Foxp3(+)CD4(+)CD25(+) Treg cells have been increasingly documented to suppress allograft rejection and to mediate allograft tolerance in transplantation. In this article, the authors review current approaches for amplification of allo-specific Foxp3(+)CD4(+)CD25(+) Treg cells for prevention of allograft rejection and induction of allo-specific transplant tolerance.

Full Text

Duke Authors

Cited Authors

  • Xia, G; Shah, M; Luo, X

Published Date

  • February 2009

Published In

Volume / Issue

  • 153 / 2

Start / End Page

  • 60 - 70

PubMed ID

  • 19138650

Pubmed Central ID

  • PMC3408234

International Standard Serial Number (ISSN)

  • 1931-5244

Digital Object Identifier (DOI)

  • 10.1016/j.trsl.2008.12.001


  • eng

Conference Location

  • United States