The biochemistry of somatic hypermutation.

Published

Journal Article (Review)

Affinity maturation of the humoral response is mediated by somatic hypermutation of the immunoglobulin (Ig) genes and selection of higher-affinity B cell clones. Activation-induced cytidine deaminase (AID) is the first of a complex series of proteins that introduce these point mutations into variable regions of the Ig genes. AID deaminates deoxycytidine residues in single-stranded DNA to deoxyuridines, which are then processed by DNA replication, base excision repair (BER), or mismatch repair (MMR). In germinal center B cells, MMR, BER, and other factors are diverted from their normal roles in preserving genomic integrity to increase diversity within the Ig locus. Both AID and these components of an emerging error-prone mutasome are regulated on many levels by complex mechanisms that are only beginning to be elucidated.

Full Text

Duke Authors

Cited Authors

  • Peled, JU; Kuang, FL; Iglesias-Ussel, MD; Roa, S; Kalis, SL; Goodman, MF; Scharff, MD

Published Date

  • January 2008

Published In

Volume / Issue

  • 26 /

Start / End Page

  • 481 - 511

PubMed ID

  • 18304001

Pubmed Central ID

  • 18304001

Electronic International Standard Serial Number (EISSN)

  • 1545-3278

International Standard Serial Number (ISSN)

  • 0732-0582

Digital Object Identifier (DOI)

  • 10.1146/annurev.immunol.26.021607.090236

Language

  • eng