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Bisphosphonates target B cells to enhance humoral immune responses.

Publication ,  Journal Article
Tonti, E; Jiménez de Oya, N; Galliverti, G; Moseman, EA; Di Lucia, P; Amabile, A; Sammicheli, S; De Giovanni, M; Sironi, L; Chevrier, N ...
Published in: Cell Rep
October 31, 2013

Bisphosphonates are a class of drugs that are widely used to inhibit loss of bone mass in patients. We show here that the administration of clinically relevant doses of bisphosphonates in mice increases antibody responses to live and inactive viruses, proteins, haptens, and existing commercial vaccine formulations. Bisphosphonates exert this adjuvant-like activity in the absence of CD4(+) and γδ T cells, neutrophils, or dendritic cells, and their effect does not rely on local macrophage depletion, Toll-like receptor signaling, or the inflammasome. Rather, bisphosphonates target directly B cells and enhance B cell expansion and antibody production upon antigen encounter. These data establish bisphosphonates as an additional class of adjuvants that boost humoral immune responses.

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Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

October 31, 2013

Volume

5

Issue

2

Start / End Page

323 / 330

Location

United States

Related Subject Headings

  • Vesiculovirus
  • Toll-Like Receptors
  • Signal Transduction
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Inflammasomes
  • Immunoglobulin G
  • Immunity, Humoral
  • Humans
 

Citation

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Tonti, E., Jiménez de Oya, N., Galliverti, G., Moseman, E. A., Di Lucia, P., Amabile, A., … Iannacone, M. (2013). Bisphosphonates target B cells to enhance humoral immune responses. Cell Rep, 5(2), 323–330. https://doi.org/10.1016/j.celrep.2013.09.004
Tonti, Elena, Nereida Jiménez de Oya, Gabriele Galliverti, E Ashley Moseman, Pietro Di Lucia, Angelo Amabile, Stefano Sammicheli, et al. “Bisphosphonates target B cells to enhance humoral immune responses.Cell Rep 5, no. 2 (October 31, 2013): 323–30. https://doi.org/10.1016/j.celrep.2013.09.004.
Tonti E, Jiménez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, et al. Bisphosphonates target B cells to enhance humoral immune responses. Cell Rep. 2013 Oct 31;5(2):323–30.
Tonti, Elena, et al. “Bisphosphonates target B cells to enhance humoral immune responses.Cell Rep, vol. 5, no. 2, Oct. 2013, pp. 323–30. Pubmed, doi:10.1016/j.celrep.2013.09.004.
Tonti E, Jiménez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, Sammicheli S, De Giovanni M, Sironi L, Chevrier N, Sitia G, Gennari L, Guidotti LG, von Andrian UH, Iannacone M. Bisphosphonates target B cells to enhance humoral immune responses. Cell Rep. 2013 Oct 31;5(2):323–330.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

October 31, 2013

Volume

5

Issue

2

Start / End Page

323 / 330

Location

United States

Related Subject Headings

  • Vesiculovirus
  • Toll-Like Receptors
  • Signal Transduction
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Inflammasomes
  • Immunoglobulin G
  • Immunity, Humoral
  • Humans