A comparison of neuroinflammation to implanted microelectrodes in rat and mouse models.
Journal Article (Journal Article)
Rat models have emerged as a common tool to study neuroinflammation to intracortical microelectrodes. While a number of studies have attempted to understand the factors resulting in neuroinflammation using rat models, a complete understanding of key mechanistic pathways remains elusive. Transgenic mouse models, however, could facilitate a deeper understanding of mechanistic pathways due to an ease of genetic alteration. Therefore, the goal of the present study is to compare neuroinflammation following microelectrode implantation between the rat and the mouse model. Our study suggests that subtle differences in the classic neuroinflammatory markers exist between the animal models at both two and sixteen weeks post implantation. Most notably, neuronal densities surrounding microelectrodes were significantly lower in the rat model at two weeks, while similar densities were observed between the animal models at sixteen weeks. Physiological differences between the species and slight alterations in surgical methods are likely key contributors to the observed differences. Moving forward, we propose that differences in the time course of neuroinflammation between the animal models should be considered when trying to understand and prevent intracortical microelectrode failure.
Full Text
Duke Authors
Cited Authors
- Potter-Baker, KA; Ravikumar, M; Burke, AA; Meador, WD; Householder, KT; Buck, AC; Sunil, S; Stewart, WG; Anna, JP; Tomaszewski, WH; Capadona, JR
Published Date
- July 2014
Published In
Volume / Issue
- 35 / 22
Start / End Page
- 5637 - 5646
PubMed ID
- 24755527
Pubmed Central ID
- PMC4071936
Electronic International Standard Serial Number (EISSN)
- 1878-5905
International Standard Serial Number (ISSN)
- 0142-9612
Digital Object Identifier (DOI)
- 10.1016/j.biomaterials.2014.03.076
Language
- eng