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Scan-stratified case-control sampling for modeling blood-brain barrier integrity in multiple sclerosis.

Publication ,  Journal Article
Pomann, G-M; Sweeney, EM; Reich, DS; Staicu, A-M; Shinohara, RT
Published in: Stat Med
September 10, 2015

Multiple sclerosis (MS) is an immune-mediated neurological disease that causes morbidity and disability. In patients with MS, the accumulation of lesions in the white matter of the brain is associated with disease progression and worse clinical outcomes. Breakdown of the blood-brain barrier in newer lesions is indicative of more active disease-related processes and is a primary outcome considered in clinical trials of treatments for MS. Such abnormalities in active MS lesions are evaluated in vivo using contrast-enhanced structural MRI, during which patients receive an intravenous infusion of a costly magnetic contrast agent. In some instances, the contrast agents can have toxic effects. Recently, local image regression techniques have been shown to have modest performance for assessing the integrity of the blood-brain barrier based on imaging without contrast agents. These models have centered on the problem of cross-sectional classification in which patients are imaged at a single study visit and pre-contrast images are used to predict post-contrast imaging. In this paper, we extend these methods to incorporate historical imaging information, and we find the proposed model to exhibit improved performance. We further develop scan-stratified case-control sampling techniques that reduce the computational burden of local image regression models, while respecting the low proportion of the brain that exhibits abnormal vascular permeability.

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Published In

Stat Med

DOI

EISSN

1097-0258

Publication Date

September 10, 2015

Volume

34

Issue

20

Start / End Page

2872 / 2880

Location

England

Related Subject Headings

  • Statistics & Probability
  • Multiple Sclerosis
  • Magnetic Resonance Imaging
  • Logistic Models
  • Imaging, Three-Dimensional
  • Humans
  • Contrast Media
  • Case-Control Studies
  • Brain
  • Blood-Brain Barrier
 

Citation

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Pomann, G.-M., Sweeney, E. M., Reich, D. S., Staicu, A.-M., & Shinohara, R. T. (2015). Scan-stratified case-control sampling for modeling blood-brain barrier integrity in multiple sclerosis. Stat Med, 34(20), 2872–2880. https://doi.org/10.1002/sim.6520
Pomann, Gina-Maria, Elizabeth M. Sweeney, Daniel S. Reich, Ana-Maria Staicu, and Russell T. Shinohara. “Scan-stratified case-control sampling for modeling blood-brain barrier integrity in multiple sclerosis.Stat Med 34, no. 20 (September 10, 2015): 2872–80. https://doi.org/10.1002/sim.6520.
Pomann G-M, Sweeney EM, Reich DS, Staicu A-M, Shinohara RT. Scan-stratified case-control sampling for modeling blood-brain barrier integrity in multiple sclerosis. Stat Med. 2015 Sep 10;34(20):2872–80.
Pomann, Gina-Maria, et al. “Scan-stratified case-control sampling for modeling blood-brain barrier integrity in multiple sclerosis.Stat Med, vol. 34, no. 20, Sept. 2015, pp. 2872–80. Pubmed, doi:10.1002/sim.6520.
Pomann G-M, Sweeney EM, Reich DS, Staicu A-M, Shinohara RT. Scan-stratified case-control sampling for modeling blood-brain barrier integrity in multiple sclerosis. Stat Med. 2015 Sep 10;34(20):2872–2880.
Journal cover image

Published In

Stat Med

DOI

EISSN

1097-0258

Publication Date

September 10, 2015

Volume

34

Issue

20

Start / End Page

2872 / 2880

Location

England

Related Subject Headings

  • Statistics & Probability
  • Multiple Sclerosis
  • Magnetic Resonance Imaging
  • Logistic Models
  • Imaging, Three-Dimensional
  • Humans
  • Contrast Media
  • Case-Control Studies
  • Brain
  • Blood-Brain Barrier