Environment matters: microglia function and dysfunction in a changing world.

Journal Article (Review;Journal Article)

The immune system is our interface with the environment, and immune molecules such as cytokines and chemokines and the cells that produce them within the brain, notably microglia, are critical for normal brain development. This recognition has in recent years led to the working hypothesis that inflammatory events during pregnancy or the early postnatal period, for example, in response to infection, may disrupt the normal developmental trajectory of microglia and consequently their interactions with neurons, thereby contributing to the risk for neurological disorders. The current article outlines recent findings on the impact of diverse, pervasive environmental challenges, beyond infection, including air pollution and maternal stress; and their impact on microglial development and its broad implications for neural pathologies.

Full Text

Duke Authors

Cited Authors

  • Hanamsagar, R; Bilbo, SD

Published Date

  • December 2017

Published In

Volume / Issue

  • 47 /

Start / End Page

  • 146 - 155

PubMed ID

  • 29096243

Pubmed Central ID

  • PMC5732848

Electronic International Standard Serial Number (EISSN)

  • 1873-6882

International Standard Serial Number (ISSN)

  • 0959-4388

Digital Object Identifier (DOI)

  • 10.1016/j.conb.2017.10.007


  • eng