Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy.
Journal Article (Journal Article)
Systemic IL12 therapy has potent antitumor effects, but clinical delivery of this potent cytokine has been complicated by systemic toxicity. A novel strategy to deliver IL12 to the tumor microenvironment appears promising in a first-in-human study, appearing to stimulate tumor-specific adaptive immune responses with minimal systemic toxicity.See related article by Strauss et al., p. 99.
- Lyerly, HK; Osada, T; Hartman, ZC
- January 1, 2019
Volume / Issue
- 25 / 1
Start / End Page
- 9 - 11
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)
- United States