Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy.
Publication
, Journal Article
Lyerly, HK; Osada, T; Hartman, ZC
Published in: Clin Cancer Res
January 1, 2019
Systemic IL12 therapy has potent antitumor effects, but clinical delivery of this potent cytokine has been complicated by systemic toxicity. A novel strategy to deliver IL12 to the tumor microenvironment appears promising in a first-in-human study, appearing to stimulate tumor-specific adaptive immune responses with minimal systemic toxicity.See related article by Strauss et al., p. 99.
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Published In
Clin Cancer Res
DOI
EISSN
1557-3265
Publication Date
January 1, 2019
Volume
25
Issue
1
Start / End Page
9 / 11
Location
United States
Related Subject Headings
- Tumor Microenvironment
- State Medicine
- Oncology & Carcinogenesis
- Neoplasms
- Interleukin-12
- Humans
- Cytokines
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Lyerly, H. K., Osada, T., & Hartman, Z. C. (2019). Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy. Clin Cancer Res, 25(1), 9–11. https://doi.org/10.1158/1078-0432.CCR-18-2819
Lyerly, H Kim, Takuya Osada, and Zachary C. Hartman. “Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy.” Clin Cancer Res 25, no. 1 (January 1, 2019): 9–11. https://doi.org/10.1158/1078-0432.CCR-18-2819.
Lyerly HK, Osada T, Hartman ZC. Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy. Clin Cancer Res. 2019 Jan 1;25(1):9–11.
Lyerly, H. Kim, et al. “Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy.” Clin Cancer Res, vol. 25, no. 1, Jan. 2019, pp. 9–11. Pubmed, doi:10.1158/1078-0432.CCR-18-2819.
Lyerly HK, Osada T, Hartman ZC. Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy. Clin Cancer Res. 2019 Jan 1;25(1):9–11.
Published In
Clin Cancer Res
DOI
EISSN
1557-3265
Publication Date
January 1, 2019
Volume
25
Issue
1
Start / End Page
9 / 11
Location
United States
Related Subject Headings
- Tumor Microenvironment
- State Medicine
- Oncology & Carcinogenesis
- Neoplasms
- Interleukin-12
- Humans
- Cytokines
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences
- 1112 Oncology and Carcinogenesis