Right Time and Place for IL12: Targeted Delivery Stimulates Immune Therapy.
Systemic IL12 therapy has potent antitumor effects, but clinical delivery of this potent cytokine has been complicated by systemic toxicity. A novel strategy to deliver IL12 to the tumor microenvironment appears promising in a first-in-human study, appearing to stimulate tumor-specific adaptive immune responses with minimal systemic toxicity.See related article by Strauss et al., p. 99.
Lyerly, HK; Osada, T; Hartman, ZC
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