Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles.

Published

Journal Article

Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing systemic discharge of prestored proinflammatory mediators. As MCs are extravascular, how they perceive circulating allergens remains a conundrum. Here, we describe the existence of a CD301b+ perivascular dendritic cell (DC) subset that continuously samples blood and relays antigens to neighboring MCs, which vigorously degranulate and trigger anaphylaxis. DC antigen transfer involves the active discharge of surface-associated antigens on 0.5- to 1.0-micrometer microvesicles (MVs) generated by vacuolar protein sorting 4 (VPS4). Antigen sharing by DCs is not limited to MCs, as neighboring DCs also acquire antigen-bearing MVs. This capacity of DCs to distribute antigen-bearing MVs to various immune cells in the perivascular space potentiates inflammatory and immune responses to blood-borne antigens.

Full Text

Duke Authors

Cited Authors

  • Choi, HW; Suwanpradid, J; Kim, IH; Staats, HF; Haniffa, M; MacLeod, AS; Abraham, SN

Published Date

  • November 9, 2018

Published In

Volume / Issue

  • 362 / 6415

PubMed ID

  • 30409859

Pubmed Central ID

  • 30409859

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.aao0666

Language

  • eng

Conference Location

  • United States