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Sulfonylurea receptor 1 expression is variable in adult and pediatric brain tumors.

Publication ,  Journal Article
Thompson, EM; Halvorson, K; McLendon, R
Published in: Clin Neuropathol
2018

INTRODUCTION: Edema is a significant cause of neuromorbidity in children and adults with brain tumors. Agents used to control this effect, such as corticosteroids, have their own associated morbidities. Sulfonylurea receptor 1 (SUR1) is a transmembrane protein that regulates the activity of ion channels in neurons, glia, and endothelial cells. SUR1 expression is upregulated in neuroinflammatory conditions. Inhibition of SUR1 with glyburide decreases edema and neuroinflammation by countering cytotoxic edema and apoptosis in rodent models of subarachnoid hemorrhage, stroke, trauma, and cerebral metastases. However, the expression of SUR1 in human brain tumors has not been elucidated. The purpose of this study was to determine SUR1 expression and cellular colocalization in a variety of human brain tumor specimens. MATERIALS AND METHODS: Six glioblastoma, 12 cerebral metastases, 11 medulloblastoma, 9 supratentorial ependymoma, and 8 posterior fossa ependymoma specimens were analyzed using immunofluorescence. SUR1 expression and colocalization with blood vessels, neurons, and glial cells was analyzed and compared using ANOVA. RESULTS: SUR1 expression was found in all specimens examined as a percentage of the total tissue area (mean ± SD): glioblastoma 3.9 ± 4, cerebral metastases 4.1 ± 3.1, medulloblastoma 8.2 ± 7.2, supratentorial ependymoma 9.1 ± 7, and posterior fossa ependymoma 8.1 ± 5.9. SUR1 expression was greater in supratentorial ependymoma compared to glioblastoma and metastases (p < 0.05) and greater in medulloblastoma compared to glioblastoma (p < 0.05). SUR1 colocalized most reliably with the neuronal marker, NeuN, in glioblastoma, metastases, and posterior fossa ependymoma samples (p < 0.05). SUR1 colocalized most reliably with the endothelial cell marker, CD31, in medulloblastoma samples (p < 0.05). CONCLUSION: SUR1 is a putative therapeutic target to reduce neuroinflammation in adult and pediatric brain tumors. Inhibition of SUR1 may result in neuronal stabilization in glioblastoma, cerebral metastases, and posterior fossa ependymoma and reduced edema in medulloblastoma.
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Published In

Clin Neuropathol

DOI

ISSN

0722-5091

Publication Date

2018

Volume

37

Issue

5

Start / End Page

221 / 227

Location

Germany

Related Subject Headings

  • Sulfonylurea Receptors
  • Neurons
  • Neurology & Neurosurgery
  • Neuroglia
  • Neoplasm Metastasis
  • Inflammation
  • Humans
  • Endothelial Cells
  • Child
  • Brain Neoplasms
 

Citation

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ICMJE
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Thompson, E. M., Halvorson, K., & McLendon, R. (2018). Sulfonylurea receptor 1 expression is variable in adult and pediatric brain tumors. Clin Neuropathol, 37(5), 221–227. https://doi.org/10.5414/NP301102
Thompson, Eric M., Kyle Halvorson, and Roger McLendon. “Sulfonylurea receptor 1 expression is variable in adult and pediatric brain tumors.Clin Neuropathol 37, no. 5 (2018): 221–27. https://doi.org/10.5414/NP301102.
Thompson EM, Halvorson K, McLendon R. Sulfonylurea receptor 1 expression is variable in adult and pediatric brain tumors. Clin Neuropathol. 2018;37(5):221–7.
Thompson, Eric M., et al. “Sulfonylurea receptor 1 expression is variable in adult and pediatric brain tumors.Clin Neuropathol, vol. 37, no. 5, 2018, pp. 221–27. Pubmed, doi:10.5414/NP301102.
Thompson EM, Halvorson K, McLendon R. Sulfonylurea receptor 1 expression is variable in adult and pediatric brain tumors. Clin Neuropathol. 2018;37(5):221–227.

Published In

Clin Neuropathol

DOI

ISSN

0722-5091

Publication Date

2018

Volume

37

Issue

5

Start / End Page

221 / 227

Location

Germany

Related Subject Headings

  • Sulfonylurea Receptors
  • Neurons
  • Neurology & Neurosurgery
  • Neuroglia
  • Neoplasm Metastasis
  • Inflammation
  • Humans
  • Endothelial Cells
  • Child
  • Brain Neoplasms