An international perspective on hospitalized patients with viral community-acquired pneumonia.

Published

Journal Article

BACKGROUND:Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. METHODS:Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. RESULTS:553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01-2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02-2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%. CONCLUSION:In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.

Full Text

Duke Authors

Cited Authors

  • Radovanovic, D; Sotgiu, G; Jankovic, M; Mahesh, PA; Marcos, PJ; Abdalla, MI; Di Pasquale, MF; Gramegna, A; Terraneo, S; Blasi, F; Santus, P; Aliberti, S; Reyes, LF; Restrepo, MI; GLIMP Study Group,

Published Date

  • February 2019

Published In

Volume / Issue

  • 60 /

Start / End Page

  • 54 - 70

PubMed ID

  • 30401576

Pubmed Central ID

  • 30401576

Electronic International Standard Serial Number (EISSN)

  • 1879-0828

International Standard Serial Number (ISSN)

  • 0953-6205

Digital Object Identifier (DOI)

  • 10.1016/j.ejim.2018.10.020

Language

  • eng