Depressive Symptoms at HIV Testing and Two-Year All-Cause Mortality Among Men Who Inject Drugs in Vietnam.

Journal Article (Journal Article)

People who inject drugs (PWID) with HIV experience an elevated risk of death. A potentially important determinant of survival is the high burden of depression. This study examined the relationship of depressive symptoms at HIV testing with 2-year all-cause mortality among newly diagnosed HIV-positive PWID in Vietnam. At HIV testing, 141 PWID (42%) experienced severe depressive symptoms, and over the 2 years following diagnosis, 82 PWID (24%) died. Controlling for potential confounders, the 2-year risk of death among those with depressive symptoms was 9.7% (95% CI - 1.2, 20.6%) higher than the risk among those without depressive symptoms. This increased risk of mortality for PWID with depressive symptoms was relatively consistent throughout the 2-year period: at 6, 12, and 18 months, the risk difference was 12.6% (5.5-19.7%), 13.9% (4.6-23.2%), and 11.0% (0.9-21.1%), respectively. HIV diagnosis may provide an important opportunity for depression screening and treatment, subsequently improving survival in this key population.Trial registry: NCT01689545.

Full Text

Duke Authors

Cited Authors

  • Levintow, SN; Pence, BW; Ha, TV; Le Minh, N; Sripaipan, T; Latkin, CA; Vu, PT; Quan, VM; Frangakis, C; Go, VF

Published Date

  • March 2019

Published In

Volume / Issue

  • 23 / 3

Start / End Page

  • 609 - 616

PubMed ID

  • 30357641

Pubmed Central ID

  • PMC6408284

Electronic International Standard Serial Number (EISSN)

  • 1573-3254

Digital Object Identifier (DOI)

  • 10.1007/s10461-018-2318-8


  • eng

Conference Location

  • United States