Depressive Symptoms at HIV Testing and Two-Year All-Cause Mortality Among Men Who Inject Drugs in Vietnam.
Journal Article (Journal Article)
People who inject drugs (PWID) with HIV experience an elevated risk of death. A potentially important determinant of survival is the high burden of depression. This study examined the relationship of depressive symptoms at HIV testing with 2-year all-cause mortality among newly diagnosed HIV-positive PWID in Vietnam. At HIV testing, 141 PWID (42%) experienced severe depressive symptoms, and over the 2 years following diagnosis, 82 PWID (24%) died. Controlling for potential confounders, the 2-year risk of death among those with depressive symptoms was 9.7% (95% CI - 1.2, 20.6%) higher than the risk among those without depressive symptoms. This increased risk of mortality for PWID with depressive symptoms was relatively consistent throughout the 2-year period: at 6, 12, and 18 months, the risk difference was 12.6% (5.5-19.7%), 13.9% (4.6-23.2%), and 11.0% (0.9-21.1%), respectively. HIV diagnosis may provide an important opportunity for depression screening and treatment, subsequently improving survival in this key population.Trial registry: ClinicalTrials.gov NCT01689545.
Full Text
Duke Authors
Cited Authors
- Levintow, SN; Pence, BW; Ha, TV; Le Minh, N; Sripaipan, T; Latkin, CA; Vu, PT; Quan, VM; Frangakis, C; Go, VF
Published Date
- March 2019
Published In
Volume / Issue
- 23 / 3
Start / End Page
- 609 - 616
PubMed ID
- 30357641
Pubmed Central ID
- PMC6408284
Electronic International Standard Serial Number (EISSN)
- 1573-3254
Digital Object Identifier (DOI)
- 10.1007/s10461-018-2318-8
Language
- eng
Conference Location
- United States