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West African Ancestry and Nocturnal Blood Pressure in African Americans: The Jackson Heart Study.

Publication ,  Journal Article
Booth, JN; Li, M; Shimbo, D; Hess, R; Irvin, MR; Kittles, R; Wilson, JG; Jorde, LB; Cheung, AK; Lange, LA; Lange, EM; Yano, Y; Muntner, P; Bress, AP
Published in: Am J Hypertens
May 7, 2018

BACKGROUND: African Americans have a higher prevalence of nocturnal hypertension and nondipping blood pressure than European Americans, but the genetic contribution to these racial differences remains unclear. We assessed the association of the percentage West African genetic ancestry with nocturnal hypertension and nondipping blood pressure in 932 African Americans from the Jackson Heart Study. METHODS: Using percentage West African ancestry determined from 389 ancestry informative markers, participants were categorized into tertiles (tertile 1 [low]: <79.3%, tertile 2: ≥79.3-86.3%, and tertile 3 [high]: >86.3%). Nocturnal hypertension was defined as mean nighttime (midnight-6 am) systolic (SBP)/diastolic blood pressure ≥120/70 mm Hg. Nondipping blood pressure was defined as mean nighttime-to-daytime (10 am-8 pm) SBP ratio >0.90. RESULTS: Nocturnal hypertension was present in 57.9% of participants; 66.6% had nondipping blood pressure. The mean age was 59.4 years, 32.8% were male, and 56.0% were taking antihypertensive medication. The prevalence ratios (95% confidence interval) adjusted for age, sex, cardiovascular disease risk factors, and socioeconomic and psychosocial factors comparing participants with moderate and high to those with low percentage West African ancestry for nocturnal hypertension were 0.98 (0.87-1.10) and 0.95 (0.84-1.08), respectively, and for nondipping blood pressure was 0.96 (0.86-1.07) and 0.98 (0.88-1.09), respectively. CONCLUSIONS: West African ancestry was not associated with nocturnal hypertension and nondipping blood pressure among African Americans. While rare genetic variants cannot be ruled out, these data highlight the need to better understand how environmental and behavioral factors contribute to differences in nocturnal blood pressure among African Americans compared with European Americans.

Duke Scholars

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

May 7, 2018

Volume

31

Issue

6

Start / End Page

706 / 714

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Longitudinal Studies
  • Hypertension
  • Humans
  • Female
  • Circadian Rhythm
  • Cardiovascular System & Hematology
  • Blood Pressure
  • Black or African American
 

Citation

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Booth, J. N., Li, M., Shimbo, D., Hess, R., Irvin, M. R., Kittles, R., … Bress, A. P. (2018). West African Ancestry and Nocturnal Blood Pressure in African Americans: The Jackson Heart Study. Am J Hypertens, 31(6), 706–714. https://doi.org/10.1093/ajh/hpy038
Booth, John N., Man Li, Daichi Shimbo, Rachel Hess, Marguerite R. Irvin, Rick Kittles, James G. Wilson, et al. “West African Ancestry and Nocturnal Blood Pressure in African Americans: The Jackson Heart Study.Am J Hypertens 31, no. 6 (May 7, 2018): 706–14. https://doi.org/10.1093/ajh/hpy038.
Booth JN, Li M, Shimbo D, Hess R, Irvin MR, Kittles R, et al. West African Ancestry and Nocturnal Blood Pressure in African Americans: The Jackson Heart Study. Am J Hypertens. 2018 May 7;31(6):706–14.
Booth, John N., et al. “West African Ancestry and Nocturnal Blood Pressure in African Americans: The Jackson Heart Study.Am J Hypertens, vol. 31, no. 6, May 2018, pp. 706–14. Pubmed, doi:10.1093/ajh/hpy038.
Booth JN, Li M, Shimbo D, Hess R, Irvin MR, Kittles R, Wilson JG, Jorde LB, Cheung AK, Lange LA, Lange EM, Yano Y, Muntner P, Bress AP. West African Ancestry and Nocturnal Blood Pressure in African Americans: The Jackson Heart Study. Am J Hypertens. 2018 May 7;31(6):706–714.
Journal cover image

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

May 7, 2018

Volume

31

Issue

6

Start / End Page

706 / 714

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Longitudinal Studies
  • Hypertension
  • Humans
  • Female
  • Circadian Rhythm
  • Cardiovascular System & Hematology
  • Blood Pressure
  • Black or African American