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Peak lung function during young adulthood and future long-term blood pressure variability: The Coronary Artery Risk Development in Young Adults (CARDIA) study.

Publication ,  Journal Article
Tedla, YG; Yano, Y; Thyagarajan, B; Kalhan, R; Viera, AJ; Rosenberg, S; Greenland, P; Carnethon, MR
Published in: Atherosclerosis
August 2018

BACKGROUND AND AIMS: Long-term blood pressure variability (BPV) is associated with cardiovascular events independent of mean blood pressure (BP); however, little is known about its predictors. METHODS: Using data from the CARDIA study, we investigated the association between peak lung-function and long-term BPV in 2917 individuals (mean age 24.8 years, 45.3% males, 58.6% whites) who were not taking antihypertensive medications. Lung-function was measured using forced vital capacity (FVC) and forced expiratory volume in 1-s (FEV1) at years 0, 2, 5, 10 and 20 and the maximum score attained was considered as peak lung-function. Variability independent of the mean (VIM) and coefficient of variation (CV) of BP were calculated to quantify BPV since achieving peak lung-function across 9 visits over 30 years. RESULTS: In a multivariate linear regression models, individuals in the 2nd (-0.64 mmHg; 95% CI: -1.06, -0.19), 3rd (-0.96; -1.47, -0.45), and 4th (-0.85: -1.53, -0.17) quartiles of FVC had lower VIM of systolic BP than the those in quartile 1 (p-trend = 0.005). CV of systolic BP was also lower by -0.58 (-0.98, -0.19), -0.92 (-1.42, -0.43), and -0.74 (-1.40, -0.08) percentage points, in the three progressively higher quartiles of FVC compared to quartile 1 (p-trend = 0.008). Similar findings were observed when the outcome was diastolic BPV. There was no association of FEV1 and FEV1-to-FVC ratio with BPV. CONCLUSIONS: These findings suggest that smaller lung volume or restrictive lung disease during young adulthood, which result in lower peak FVC, may independently increase the risk of higher long-term BPV during middle adulthood.

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Published In

Atherosclerosis

DOI

EISSN

1879-1484

Publication Date

August 2018

Volume

275

Start / End Page

225 / 231

Location

Ireland

Related Subject Headings

  • Young Adult
  • Vital Capacity
  • United States
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Male
  • Lung Volume Measurements
  • Lung Diseases
 

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Tedla, Y. G., Yano, Y., Thyagarajan, B., Kalhan, R., Viera, A. J., Rosenberg, S., … Carnethon, M. R. (2018). Peak lung function during young adulthood and future long-term blood pressure variability: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Atherosclerosis, 275, 225–231. https://doi.org/10.1016/j.atherosclerosis.2018.06.816
Tedla, Yacob G., Yuichiro Yano, Bharat Thyagarajan, Ravi Kalhan, Anthony J. Viera, Sharon Rosenberg, Philip Greenland, and Mercedes R. Carnethon. “Peak lung function during young adulthood and future long-term blood pressure variability: The Coronary Artery Risk Development in Young Adults (CARDIA) study.Atherosclerosis 275 (August 2018): 225–31. https://doi.org/10.1016/j.atherosclerosis.2018.06.816.
Tedla YG, Yano Y, Thyagarajan B, Kalhan R, Viera AJ, Rosenberg S, et al. Peak lung function during young adulthood and future long-term blood pressure variability: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Atherosclerosis. 2018 Aug;275:225–31.
Tedla, Yacob G., et al. “Peak lung function during young adulthood and future long-term blood pressure variability: The Coronary Artery Risk Development in Young Adults (CARDIA) study.Atherosclerosis, vol. 275, Aug. 2018, pp. 225–31. Pubmed, doi:10.1016/j.atherosclerosis.2018.06.816.
Tedla YG, Yano Y, Thyagarajan B, Kalhan R, Viera AJ, Rosenberg S, Greenland P, Carnethon MR. Peak lung function during young adulthood and future long-term blood pressure variability: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Atherosclerosis. 2018 Aug;275:225–231.
Journal cover image

Published In

Atherosclerosis

DOI

EISSN

1879-1484

Publication Date

August 2018

Volume

275

Start / End Page

225 / 231

Location

Ireland

Related Subject Headings

  • Young Adult
  • Vital Capacity
  • United States
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Prognosis
  • Male
  • Lung Volume Measurements
  • Lung Diseases