Comparison of morning vs bedtime administration of the combination of valsartan/amlodipine on nocturnal brachial and central blood pressure in patients with hypertension.


Journal Article

The aim of this study was to compare the effect of morning and bedtime administration of valsartan/amlodipine combination therapy (80/5 mg) on nocturnal brachial and central blood pressure (BP) measured by ambulatory BP monitoring in patients with hypertension. This was a 16-week prospective, multicenter, randomized, open-label, crossover, noninferiority clinical trial. Patients underwent 24-hour ambulatory BP monitoring at randomization, at switching, and at the end of the study. Twenty-three patients (mean age, 68.0 years) were studied. The difference in nocturnal brachial systolic BP between the morning and bedtime administrations of combination valsartan/amlodipine was -3.2 mm Hg, and the two-sided 95% confidence interval ranged from -6.8 to 0.4 mm Hg. The difference in nocturnal central systolic BP was -4.0 mm Hg (95% confidence interval, -7.6 to -0.4 mm Hg). The upper limit of the 95% confidence interval was below the margin of 3.0 mm Hg in both nocturnal brachial and central systolic BP, confirming the noninferiority of morning administration to the bedtime administration of valsartan/amlodipine combination therapy.

Full Text

Duke Authors

Cited Authors

  • Fujiwara, T; Hoshide, S; Yano, Y; Kanegae, H; Kario, K

Published Date

  • December 2017

Published In

Volume / Issue

  • 19 / 12

Start / End Page

  • 1319 - 1326

PubMed ID

  • 29106031

Pubmed Central ID

  • 29106031

Electronic International Standard Serial Number (EISSN)

  • 1751-7176

Digital Object Identifier (DOI)

  • 10.1111/jch.13128


  • eng

Conference Location

  • United States