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Cardiovascular health in young adulthood and structural brain MRI in midlife: The CARDIA study.

Publication ,  Journal Article
Bancks, MP; Allen, NB; Dubey, P; Launer, LJ; Lloyd-Jones, DM; Reis, JP; Sidney, S; Yano, Y; Schreiner, PJ
Published in: Neurology
August 15, 2017

OBJECTIVE: To examine the association between the American Heart Association (AHA) Life's Simple 7 (LS7) metric and brain structure. METHODS: We determined cardiovascular health (CVH) according to the AHA LS7, assigning 0, 1, or 2 points for meeting poor, intermediate, or ideal criteria for the 7 components (range 0-14) at baseline (aged 18-30 years in 1985-1986) and year 25 follow-up examination for 518 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) brain MRI substudy. Visit-based CVH score and average score was assessed in relation to percent of intracranial volume of normal tissue of the whole brain, gray matter, and white matter, and abnormal tissue volume of white matter at year 25 using multivariable linear, logistic, and quantile regression, after adjustment for age, sex, race, field center, educational attainment, and alcohol consumption. RESULTS: Mean percentage of whole brain volume, normal gray matter, and normal white matter was 81.3% (±2.5), 42.9% (±2.0), and 38.4% (±2.0). Greater CVH score at baseline (per each additional point at year 0: 0.1%, 95% confidence limits 0.01-0.3; p < 0.05) and average CVH score were associated with greater percentage of whole brain volume (per each additional point in average score: 0.2%, 95% confidence limits 0.04-0.3; p < 0.05). Visit-based or average CVH score was not significantly associated with normal gray or white matter volume or abnormal white matter volume. CONCLUSIONS: Maintaining ideal levels of cardiovascular health, determined by the LS7, in young adulthood is associated with greater whole brain volume in middle age but not regional differences in structure.

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Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

August 15, 2017

Volume

89

Issue

7

Start / End Page

680 / 686

Location

United States

Related Subject Headings

  • Young Adult
  • White Matter
  • Urban Population
  • United States
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Longitudinal Studies
  • Humans
 

Citation

APA
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ICMJE
MLA
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Bancks, M. P., Allen, N. B., Dubey, P., Launer, L. J., Lloyd-Jones, D. M., Reis, J. P., … Schreiner, P. J. (2017). Cardiovascular health in young adulthood and structural brain MRI in midlife: The CARDIA study. Neurology, 89(7), 680–686. https://doi.org/10.1212/WNL.0000000000004222
Bancks, Michael P., Norrina B. Allen, Prachi Dubey, Lenore J. Launer, Donald M. Lloyd-Jones, Jared P. Reis, Stephen Sidney, Yuichiro Yano, and Pamela J. Schreiner. “Cardiovascular health in young adulthood and structural brain MRI in midlife: The CARDIA study.Neurology 89, no. 7 (August 15, 2017): 680–86. https://doi.org/10.1212/WNL.0000000000004222.
Bancks MP, Allen NB, Dubey P, Launer LJ, Lloyd-Jones DM, Reis JP, et al. Cardiovascular health in young adulthood and structural brain MRI in midlife: The CARDIA study. Neurology. 2017 Aug 15;89(7):680–6.
Bancks, Michael P., et al. “Cardiovascular health in young adulthood and structural brain MRI in midlife: The CARDIA study.Neurology, vol. 89, no. 7, Aug. 2017, pp. 680–86. Pubmed, doi:10.1212/WNL.0000000000004222.
Bancks MP, Allen NB, Dubey P, Launer LJ, Lloyd-Jones DM, Reis JP, Sidney S, Yano Y, Schreiner PJ. Cardiovascular health in young adulthood and structural brain MRI in midlife: The CARDIA study. Neurology. 2017 Aug 15;89(7):680–686.

Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

August 15, 2017

Volume

89

Issue

7

Start / End Page

680 / 686

Location

United States

Related Subject Headings

  • Young Adult
  • White Matter
  • Urban Population
  • United States
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Longitudinal Studies
  • Humans