Isolated Systolic Hypertension in Young and Middle-Aged Adults.

Journal Article (Journal Article;Review)

Young and middle-aged adults (ages ≤50 years) are increasingly prone to stroke, kidney disease, and worsening cardiovascular disease (CVD) mortality. An alarming increase in the prevalence of high blood pressure (BP) may underlie the adverse trend. However, there is often uncertainty in BP management for young and middle-aged adults. Isolated systolic hypertension (ISH) is one such example. Whether ISH in young and middle-aged adults represents "pseudo" or "spurious" hypertension is still being debated. ISH in young and middle-aged adults is a heterogeneous entity; some individuals appear to have increased stroke volume, whereas others have stiffened aortae, or both. One size does not seem to fit all in the clinical management of ISH in young and middle-aged adults. Rather than treating ISH as a monolithic condition, detailed phenotyping of ISH based on (patho)physiology and in the context of individual global cardiovascular risks would seem to be most useful to assess an individual expected net benefit from therapy. This review provides an overview of the current understanding of ISH in young and middle-aged adults, including the prevalence, pathophysiology, and treatment.

Full Text

Duke Authors

Cited Authors

  • Yano, Y; Lloyd-Jones, DM

Published Date

  • November 2016

Published In

Volume / Issue

  • 18 / 11

Start / End Page

  • 78 -

PubMed ID

  • 27739020

Electronic International Standard Serial Number (EISSN)

  • 1534-3111

Digital Object Identifier (DOI)

  • 10.1007/s11906-016-0686-x


  • eng

Conference Location

  • United States