Sleep Blood Pressure Self-Measured at Home as a Novel Determinant of Organ Damage: Japan Morning Surge Home Blood Pressure (J-HOP) Study.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

To study whether sleep blood pressure (BP) self-measured at home is associated with organ damage, the authors analyzed the data of 2562 participants in the J-HOP study who self-measured sleep BP using a home BP monitoring (HBPM) device, three times during sleep (2 am, 3 am, 4 am), as well as the home morning and evening BPs. The mean sleep home systolic BPs (SBPs) were all correlated with urinary albumin/creatinine ratio (UACR), left ventricular mass index (LVMI), brachial-ankle pulse wave velocity (baPWV), maximum carotid intima-media thickness, and plasma N-terminal pro-hormone pro-brain-type natriuretic peptide (NTproBNP) (all P<.001). After controlling for clinic SBP and home morning and evening SBPs, associations of home sleep SBP with UACR, LVMI, and baPWV remained significant (all P<.008). Even in patients with home morning BP <135/85 mm Hg, 27% exhibited masked nocturnal hypertension with home sleep SBP ≥120 mm Hg and had higher UACR and NTproBNP. Masked nocturnal hypertension, which is associated with advanced organ damage, remains unrecognized by conventional HBPM.

Full Text

Duke Authors

Cited Authors

  • Kario, K; Hoshide, S; Haimoto, H; Yamagiwa, K; Uchiba, K; Nagasaka, S; Yano, Y; Eguchi, K; Matsui, Y; Shimizu, M; Ishikawa, J; Ishikawa, S; J-HOP study group,

Published Date

  • May 2015

Published In

Volume / Issue

  • 17 / 5

Start / End Page

  • 340 - 348

PubMed ID

  • 25689113

Pubmed Central ID

  • PMC8031719

Electronic International Standard Serial Number (EISSN)

  • 1751-7176

Digital Object Identifier (DOI)

  • 10.1111/jch.12500


  • eng

Conference Location

  • United States