Sleep Blood Pressure Self-Measured at Home as a Novel Determinant of Organ Damage: Japan Morning Surge Home Blood Pressure (J-HOP) Study.
Journal Article (Clinical Trial;Journal Article;Multicenter Study)
To study whether sleep blood pressure (BP) self-measured at home is associated with organ damage, the authors analyzed the data of 2562 participants in the J-HOP study who self-measured sleep BP using a home BP monitoring (HBPM) device, three times during sleep (2 am, 3 am, 4 am), as well as the home morning and evening BPs. The mean sleep home systolic BPs (SBPs) were all correlated with urinary albumin/creatinine ratio (UACR), left ventricular mass index (LVMI), brachial-ankle pulse wave velocity (baPWV), maximum carotid intima-media thickness, and plasma N-terminal pro-hormone pro-brain-type natriuretic peptide (NTproBNP) (all P<.001). After controlling for clinic SBP and home morning and evening SBPs, associations of home sleep SBP with UACR, LVMI, and baPWV remained significant (all P<.008). Even in patients with home morning BP <135/85 mm Hg, 27% exhibited masked nocturnal hypertension with home sleep SBP ≥120 mm Hg and had higher UACR and NTproBNP. Masked nocturnal hypertension, which is associated with advanced organ damage, remains unrecognized by conventional HBPM.
Full Text
Duke Authors
Cited Authors
- Kario, K; Hoshide, S; Haimoto, H; Yamagiwa, K; Uchiba, K; Nagasaka, S; Yano, Y; Eguchi, K; Matsui, Y; Shimizu, M; Ishikawa, J; Ishikawa, S; J-HOP study group,
Published Date
- May 2015
Published In
Volume / Issue
- 17 / 5
Start / End Page
- 340 - 348
PubMed ID
- 25689113
Pubmed Central ID
- PMC8031719
Electronic International Standard Serial Number (EISSN)
- 1751-7176
Digital Object Identifier (DOI)
- 10.1111/jch.12500
Language
- eng
Conference Location
- United States