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New-onset hypertension and risk for chronic kidney disease in the Japanese general population.

Publication ,  Journal Article
Yano, Y; Fujimoto, S; Sato, Y; Konta, T; Iseki, K; Iseki, C; Moriyama, T; Yamagata, K; Tsuruya, K; Narita, I; Kondo, M; Kimura, K; Asahi, K ...
Published in: J Hypertens
December 2014

OBJECTIVES: Our aims were to assess the progression rate of normotension and prehypertension to hypertension in Japan, and the effect of the new-onset hypertension on chronic kidney disease (CKD). METHODS: This was a nationwide study of 45 378 Japanese aged 40-74 years (mean age 60 years, 37% men) without hypertension or cardiovascular disease at baseline. At baseline and 3-year follow-up, blood pressure (BP) and kidney function were assessed. CKD was defined as an estimated glomerular filtration rate (eGFR) below 60 ml/min per 1.73 m² or the presence of proteinuria (≥1+ by a dipstick). RESULTS: At 3-year follow-up, the incidence rates of hypertension among participants with optimal BP (<120/80 mmHg, n = 18,724), normal BP (120-129/80-84 mmHg, n = 15,017) and high-normal BP (130-139/85-89 mmHg, n = 11,637) were 8, 23, and 39% in men, and 6, 20, and 37% in women, respectively. Among those without CKD at baseline (n = 42,625), 2142 participants (5%) had developed CKD during follow-up. Irrespective of the baseline BP classifications, participants with new-onset hypertension had a higher risk for proteinuria [odds ratio (95% confidence interval) 1.7 (1.3-2.3) in men and 1.6 (1.2-2.2) in women], but not for eGFR below 60 ml/min per 1.73 m², compared with those who maintained optimal BP during follow-up. Men who remained in the high-normal BP range during follow-up showed higher risk for proteinuria [odds ratio (95% confidence interval) 1.6 (1.1-2.3)], but not for eGFR below 60 ml/min per 1.73 m². CONCLUSIONS: This nationwide longitudinal study suggests that, over 3 years of follow-up, women and men with new-onset hypertension and men with high-normal BP were at higher risk of newly developing proteinuria.

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Published In

J Hypertens

DOI

EISSN

1473-5598

Publication Date

December 2014

Volume

32

Issue

12

Start / End Page

2371 / 2377

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Renal Insufficiency, Chronic
  • Japan
  • Hypertension
  • Humans
  • Cardiovascular System & Hematology
  • Asian People
  • 1116 Medical Physiology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Yano, Y., Fujimoto, S., Sato, Y., Konta, T., Iseki, K., Iseki, C., … Watanabe, T. (2014). New-onset hypertension and risk for chronic kidney disease in the Japanese general population. J Hypertens, 32(12), 2371–2377. https://doi.org/10.1097/HJH.0000000000000344
Yano, Yuichiro, Shouichi Fujimoto, Yuji Sato, Tsuneo Konta, Kunitoshi Iseki, Chiho Iseki, Toshiki Moriyama, et al. “New-onset hypertension and risk for chronic kidney disease in the Japanese general population.J Hypertens 32, no. 12 (December 2014): 2371–77. https://doi.org/10.1097/HJH.0000000000000344.
Yano Y, Fujimoto S, Sato Y, Konta T, Iseki K, Iseki C, et al. New-onset hypertension and risk for chronic kidney disease in the Japanese general population. J Hypertens. 2014 Dec;32(12):2371–7.
Yano, Yuichiro, et al. “New-onset hypertension and risk for chronic kidney disease in the Japanese general population.J Hypertens, vol. 32, no. 12, Dec. 2014, pp. 2371–77. Pubmed, doi:10.1097/HJH.0000000000000344.
Yano Y, Fujimoto S, Sato Y, Konta T, Iseki K, Iseki C, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Kimura K, Asahi K, Kurahashi I, Ohashi Y, Watanabe T. New-onset hypertension and risk for chronic kidney disease in the Japanese general population. J Hypertens. 2014 Dec;32(12):2371–2377.

Published In

J Hypertens

DOI

EISSN

1473-5598

Publication Date

December 2014

Volume

32

Issue

12

Start / End Page

2371 / 2377

Location

Netherlands

Related Subject Headings

  • Risk Factors
  • Renal Insufficiency, Chronic
  • Japan
  • Hypertension
  • Humans
  • Cardiovascular System & Hematology
  • Asian People
  • 1116 Medical Physiology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology