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Association of high-sensitivity cardiac troponin T and N-terminal pro-brain-type natriuretic peptide with left ventricular structure: J-HOP study.

Publication ,  Journal Article
Hoshide, S; Nagai, M; Yano, Y; Ishikawa, J; Eguchi, K; Kario, K; Japan Morning Surge-Home Blood Pressure Study Investigators Group,
Published in: J Clin Hypertens (Greenwich)
May 2014

Although both high-sensitivity cardiac troponin T (Hs-cTnT) and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) levels are higher among patients with cardiac structural abnormalities than among those with apparently normal hearts, there is considerable overlap between the groups. The authors evaluated 1336 patients who had ≥1 cardiovascular risk factors, underwent echocardiography, and had Hs-cTnT and NT-proBNP measured and excluded patients with left ventricular (LV) dysfunction. The patients in the highest Hs-cTnT category in quintiles had an increased likelihood of abnormal relative wall thickness compared with those in the lowest category (odds ratio, 1.66; 95% confidence interval, 1.17-2.36; P<.01). However, no such association was found in the category of NT-proBNP. The patients in the highest NT-proBNP category had an increased likelihood of abnormal LV diastolic dimension/body surface area compared with those in the lowest category (odds ratio, 2.11; 95% confidence interval, 1.17-3.79; P<.05). However, no such association was found in the category of Hs-cTnT. The data suggest that the measurement of Hs-cTnT and NT-proBNP might provide information on cardiac structural abnormalities.

Duke Scholars

Published In

J Clin Hypertens (Greenwich)

DOI

EISSN

1751-7176

Publication Date

May 2014

Volume

16

Issue

5

Start / End Page

354 / 361

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Troponin T
  • Risk Factors
  • Protein Precursors
  • Prognosis
  • Peptide Fragments
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Japan
 

Citation

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Hoshide, S., Nagai, M., Yano, Y., Ishikawa, J., Eguchi, K., Kario, K., & Japan Morning Surge-Home Blood Pressure Study Investigators Group, . (2014). Association of high-sensitivity cardiac troponin T and N-terminal pro-brain-type natriuretic peptide with left ventricular structure: J-HOP study. J Clin Hypertens (Greenwich), 16(5), 354–361. https://doi.org/10.1111/jch.12321
Hoshide, Satoshi, Michiaki Nagai, Yuichiro Yano, Joji Ishikawa, Kazuo Eguchi, Kazuomi Kario, and Kazuomi Japan Morning Surge-Home Blood Pressure Study Investigators Group. “Association of high-sensitivity cardiac troponin T and N-terminal pro-brain-type natriuretic peptide with left ventricular structure: J-HOP study.J Clin Hypertens (Greenwich) 16, no. 5 (May 2014): 354–61. https://doi.org/10.1111/jch.12321.
Hoshide S, Nagai M, Yano Y, Ishikawa J, Eguchi K, Kario K, et al. Association of high-sensitivity cardiac troponin T and N-terminal pro-brain-type natriuretic peptide with left ventricular structure: J-HOP study. J Clin Hypertens (Greenwich). 2014 May;16(5):354–61.
Hoshide, Satoshi, et al. “Association of high-sensitivity cardiac troponin T and N-terminal pro-brain-type natriuretic peptide with left ventricular structure: J-HOP study.J Clin Hypertens (Greenwich), vol. 16, no. 5, May 2014, pp. 354–61. Pubmed, doi:10.1111/jch.12321.
Hoshide S, Nagai M, Yano Y, Ishikawa J, Eguchi K, Kario K, Japan Morning Surge-Home Blood Pressure Study Investigators Group. Association of high-sensitivity cardiac troponin T and N-terminal pro-brain-type natriuretic peptide with left ventricular structure: J-HOP study. J Clin Hypertens (Greenwich). 2014 May;16(5):354–361.
Journal cover image

Published In

J Clin Hypertens (Greenwich)

DOI

EISSN

1751-7176

Publication Date

May 2014

Volume

16

Issue

5

Start / End Page

354 / 361

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Troponin T
  • Risk Factors
  • Protein Precursors
  • Prognosis
  • Peptide Fragments
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Japan