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Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients.

Publication ,  Journal Article
Yano, Y; Nakazato, M; Toshinai, K; Inokuchi, T; Matsuda, S; Hidaka, T; Hayakawa, M; Kangawa, K; Shimada, K; Kario, K
Published in: Am J Hypertens
May 2014

BACKGROUND: We aimed to assess the predictive value of circulating levels of des-acyl ghrelin, an abundant form of ghrelin in humans, for the risk of cardiovascular disease (CVD) in older hypertensive patients. We simultaneously evaluated other biomarkers, such as high-molecular-weight (HMW) adiponectin, high-sensitivity C-reactive protein (hs-CRP), and plasminogen activator inhibitor 1 (PAI-1), for their usefulness in risk prediction. METHODS: We enrolled 590 older hypertensive patients (mean age = 72.9 years; 41.0% men). The incidences of CVD, including coronary artery disease, stroke, congestive heart failure, and sudden death, were prospectively ascertained. RESULTS: During an average duration of 2.8 (SD = 0.7) years (1,653 person-years), there were 42 CVD events. Patients with CVD events had lower levels of des-acyl ghrelin at baseline than those without CVD events (median = 78.2 vs. 114.7 fmol/ml; P < 0.001). No difference was found among other biomarkers between the patients with CVD events and those without such events. The Cox proportional hazards model adjusted by covariables revealed that the hazard ratio for CVD events in patients with a 1-SD decrease of log des-acyl ghrelin was 1.8 (95% confidence interval = 1.3-2.4). Incorporation of des-acyl ghrelin in the risk model (including age, current smoking, 24-hour systolic blood pressure, preexisting CVD, and carotid intima-media thickness) improved the C statistics (from 0.683 to 0.721; P = 0.22) and resulted in a net reclassification improvement of 20.5% (P = 0.02). In contrast, HMW adiponectin, hs-CRP, and PAI-1 provided no improvement in risk prediction. CONCLUSIONS: Des-acyl ghrelin improved the prediction of CVD events in older hypertensive patients.

Duke Scholars

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

May 2014

Volume

27

Issue

5

Start / End Page

727 / 733

Location

United States

Related Subject Headings

  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Proportional Hazards Models
  • Prognosis
  • Predictive Value of Tests
  • Plasminogen Activator Inhibitor 1
  • Middle Aged
  • Male
 

Citation

APA
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ICMJE
MLA
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Yano, Y., Nakazato, M., Toshinai, K., Inokuchi, T., Matsuda, S., Hidaka, T., … Kario, K. (2014). Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients. Am J Hypertens, 27(5), 727–733. https://doi.org/10.1093/ajh/hpt232
Yano, Yuichiro, Masamitsu Nakazato, Koji Toshinai, Takashi Inokuchi, Shuntaro Matsuda, Toshiaki Hidaka, Manabu Hayakawa, Kenji Kangawa, Kazuyuki Shimada, and Kazuomi Kario. “Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients.Am J Hypertens 27, no. 5 (May 2014): 727–33. https://doi.org/10.1093/ajh/hpt232.
Yano Y, Nakazato M, Toshinai K, Inokuchi T, Matsuda S, Hidaka T, et al. Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients. Am J Hypertens. 2014 May;27(5):727–33.
Yano, Yuichiro, et al. “Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients.Am J Hypertens, vol. 27, no. 5, May 2014, pp. 727–33. Pubmed, doi:10.1093/ajh/hpt232.
Yano Y, Nakazato M, Toshinai K, Inokuchi T, Matsuda S, Hidaka T, Hayakawa M, Kangawa K, Shimada K, Kario K. Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients. Am J Hypertens. 2014 May;27(5):727–733.
Journal cover image

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

May 2014

Volume

27

Issue

5

Start / End Page

727 / 733

Location

United States

Related Subject Headings

  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Proportional Hazards Models
  • Prognosis
  • Predictive Value of Tests
  • Plasminogen Activator Inhibitor 1
  • Middle Aged
  • Male